Abstract The Global Burden of Disease Study (GBD) began 30 years ago with the goal of
providing timely, valid and relevant assessments of critical health outcomes. Over this …

The past 50 years have seen a growing ageing population with an increasing prevalence of
type 2 diabetes mellitus (T2DM); now, nearly half of all individuals with diabetes mellitus are …

Background Health-care needs change throughout the life course. It is thus crucial to assess
whether health systems provide access to quality health care for all ages. Drawing from the …

Remodelling of the immune system with age—immunosenescence—is a substantial
contributor to poor health in older adults, with increasing risk of infections, cancer and …

Background Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs)
provide summary measures of health across geographies and time that can inform …

Summary Background The Global Burden of Disease Study 2013 (GBD 2013) aims to bring
together all available epidemiological data using a coherent measurement framework …

Importance Cancer is among the leading causes of death worldwide. Current estimates of
cancer burden in individual countries and regions are necessary to inform local cancer …

Objective To review literature and provide a pooled effect for the association between
multimorbidity and mortality in older adults. Methods A systematic review was performed of …

Summary Background The Global Burden of Disease (GBD) study assesses health losses
from diseases, injuries, and risk factors using disability-adjusted life-years, which need a set …

Background Up-to-date evidence on levels and trends for age-sex-specifi c all-cause and
cause-specifi c mortality is essential for the formation of global, regional, and national health …