ROS: basic concepts, sources, cellular signaling, and its implications in aging pathways
AJPO de Almeida, JCPL de Oliveira… - Oxidative medicine …, 2022 - Wiley Online Library
Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range of
molecules with oxidizing properties known as ROS. Despite those molecules being implied …
molecules with oxidizing properties known as ROS. Despite those molecules being implied …
Molecular and cellular pathways contributing to brain aging
A Zia, AM Pourbagher-Shahri, T Farkhondeh… - Behavioral and Brain …, 2021 - Springer
Aging is the leading risk factor for several age-associated diseases such as
neurodegenerative diseases. Understanding the biology of aging mechanisms is essential …
neurodegenerative diseases. Understanding the biology of aging mechanisms is essential …
In vivo amelioration of age-associated hallmarks by partial reprogramming
Aging is the major risk factor for many human diseases. In vitro studies have demonstrated
that cellular reprogramming to pluripotency reverses cellular age, but alteration of the aging …
that cellular reprogramming to pluripotency reverses cellular age, but alteration of the aging …
The path from mitochondrial ROS to aging runs through the mitochondrial permeability transition pore
H Rottenberg, JB Hoek - Aging cell, 2017 - Wiley Online Library
Excessive production of mitochondrial reactive oxygen species (mROS) is strongly
associated with mitochondrial and cellular oxidative damage, aging, and degenerative …
associated with mitochondrial and cellular oxidative damage, aging, and degenerative …
Dietary thiols accelerate aging of C. elegans
Glutathione (GSH) is the most abundant cellular antioxidant. As reactive oxygen species
(ROS) are widely believed to promote aging and age-related diseases, and antioxidants can …
(ROS) are widely believed to promote aging and age-related diseases, and antioxidants can …
Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila
Poly (ADP-ribose) polymerase-1 (PARP1) has been reported to play an important role in
longevity. Here, we showed that the knockdown of the PARP1 extended the lifespan of …
longevity. Here, we showed that the knockdown of the PARP1 extended the lifespan of …
Mitohormesis, an antiaging paradigm
C Bárcena, P Mayoral, PM Quirós - … review of cell and molecular Biology, 2018 - Elsevier
Mitohormesis is a term used to define a biological response where the induction of a
reduced amount of mitochondrial stress leads to an increment in health and viability within a …
reduced amount of mitochondrial stress leads to an increment in health and viability within a …
Unveiling the role of inflammation and oxidative stress on age‐related cardiovascular diseases
AJPO de Almeida… - Oxidative medicine …, 2020 - Wiley Online Library
The global population above 60 years has been growing exponentially in the last decades,
which is accompanied by an increase in the prevalence of age‐related chronic diseases …
which is accompanied by an increase in the prevalence of age‐related chronic diseases …
[HTML][HTML] NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle
Aging is characterized by loss of proteostasis and mitochondrial homeostasis. Here, we
provide bioinformatic evidence of dysregulation of mitochondrial and proteostasis pathways …
provide bioinformatic evidence of dysregulation of mitochondrial and proteostasis pathways …
[HTML][HTML] Sugar-induced obesity and insulin resistance are uncoupled from shortened survival in Drosophila
E van Dam, LAG van Leeuwen, E Dos Santos, J James… - Cell metabolism, 2020 - cell.com
High-sugar diets cause thirst, obesity, and metabolic dysregulation, leading to diseases
including type 2 diabetes and shortened lifespan. However, the impact of obesity and water …
including type 2 diabetes and shortened lifespan. However, the impact of obesity and water …