Mechanisms underlying the depletion of NAD+ and accumulation of reactive oxygen species
(ROS) in aging and age‐related disorders remain poorly defined. We show that reverse …

Despite the achieved progress in developing efficient MDM2-p53 protein-protein interaction
inhibitors (MDM2 inhibitors), the acquired resistance of tumor cells to such p53 activators …

Both life span and health span are influenced by genetic, environmental and lifestyle factors.
With the genetic influence on human life span estimated to be about 20–25%, epigenetic …

The mammalian circadian clockwork has evolved as a timing system that allows the daily
environmental changes to be anticipated so that behavior and tissue physiology can be …

Aging is a physiologic/pathologic process characterized by a progressive impairment of
cellular functions, supported by the alterations of several molecular pathways, leading to an …

Mitochondria play an essential role in ageing and longevity. During ageing, a general
deregulation of metabolism occurs, affecting molecular, cellular and physiological activities …

In all eukaryotes, the mechanistic target of rapamycin (mTOR) signaling emerges as a
master regulator of homeostasis, which integrates environmental inputs, including nutrients …

The field of comparative ageing biology has greatly expanded in the past 20 years.
Longitudinal studies of populations of reptiles with a range of maximum lifespans have …

Aging is a biological process determined by multiple cellular mechanisms, such as genomic
instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient …

Aging is a physiological process in which multifactorial processes determine a progressive
decline. Several alterations contribute to the aging process, including telomere shortening …