Mitochondrial dysfunction can either extend or decrease Caenorhabditis elegans lifespan,
depending on whether transcriptionally regulated responses can elicit durable stress …

Ageing is a conserved biological process, modulated by intrinsic and extrinsic factors, that
leads to changes in life expectancy. In humans, ageing is characterized by greatly increased …

Senescent cells produce chronic inflammation that contributes to the diseases and debilities
of aging. How this process is orchestrated in epithelial cells, the origin of human carcinomas …

Cellular heterogeneity is an important contributor to biological function and is employed by
cells, tissues and organisms to adapt, compensate, respond, defend and/or regulate specific …

Aging is a complex and highly variable process. Heritability of longevity among humans and
other species is low, and this finding has given rise to the idea that it may be futile to search …

As an important fruit pest of global significance, Drosophila suzukii occupies a special
ecological niche, with the characteristics of high sugar and low protein contents. This niche …

In other species characterized to date, aging, as a function of reproductive potential, results
in the breakdown of proteaostasis and a decreased capacity to mount responses by the heat …

Abstract Heat shock factor 1 (HSF-1) is a component of the heat shock response pathway
that is induced by cytoplasmic proteotoxic stress. In addition to its role in stress response …

Ageing exhibits common and distinct features in various tissues, making it critical to decipher
the tissue-specific ageing mechanisms. MiRNAs are essential regulators in ageing and are …

Sexual interactions have a potent influence on health in several species, including
mammals. Previous work in C. elegans identified strategies used by males to accelerate the …