As an ancient cellular co-factor ubiquitously present in all domains of life, nearly all iron-
sulfur ([Fe-S]) clusters are assembled in the mitochondrion. Although multiple mitochondrion …

Ageing is co-regulated by genetic and environmental factors. Life on earth lives and evolves
in a mild geomagnetic field. Yet, the biological effects of a moderate magnetic field on …

The regulation of gene expression is a fundamental process enabling cells to respond to
internal and external stimuli or to execute developmental programs. Changes in gene …

Neuroprotection strategies to improve stroke outcome have been successful in the
laboratory but not in clinical stroke trials, and thus have come under scrutiny by the medical …

Dietary restriction (DR) is known to have a potent and conserved longevity effect, yet its
underlying molecular mechanisms remain elusive. DR modulates signaling pathways in …

Biology of Aging, Second Edition presents the biological principles that have led to a new
understanding of the causes of aging and describes how these basic principles help one to …

The insulin/IGF signalling pathway impacts lifespan across distant taxa, by controlling the
activity of nodal transcription factors. In the nematode Caenorhabditis elegans, the …

Protein homeostasis is remodeled early in Caenorhabditis elegans adulthood, resulting in a
sharp decline in folding capacity and reduced ability to cope with chronic and acute stress …

Many of the leading causes of death in humans, such as cardiovascular disease, type 2
diabetes and Alzheimer's disease are influenced by biological mechanisms that become …

Nearly every system within the body contains an intrinsic cellular circadian clock. The
circadian clock contributes to the regulation of a variety of homeostatic processes in …