To date, the application of oxygen-ozone (O2O3) therapy has significantly increased in the
common clinical practice in several pathological conditions. However, beyond the favorable …

Diabetic foot ulcers (DFUs) are very important diabetes-related lesions that can lead to
serious physical consequences like amputations of limbs and equally severe social …

The search for a wide spectrum of antimicrobial agents that can avoid resistance while
maintaining reasonable side effects has led to ozonated oils experiencing an increase in …

Abstract Systems medicine is founded on a mechanism-based approach and identifies in
this way specific therapeutic targets. This approach has been applied for the transcription …

This study aims at evaluating the efficacy and safety of ozone therapy for chronic wounds.
The Cochrane Library, PubMed, Ovid Embase, Web of Science, and Chinese Biomedical …

Introduction The Brazil has one of the largest public health systems in the world and in the
1980's, Traditional, Complementary and Integrative Medicine were introduced. In 2018, the …

The problematic combination of a rising prevalence of skin and soft tissue infections and the
growing rate of life-threatening antibiotic resistant infections presents an urgent, unmet need …

In the last decade, cognitive frailty has gained great attention from the scientific community. It
is characterized by high inflammation and oxidant state, endocrine and metabolic …

Ozone has been successfully used in medicine for over 100 years due to its microbiological
qualities. Its powerful oxidation impact, which results in the production of free radicals, and …

The purpose of this study is to review the current knowledge of oxygen-ozone (O2-O3)
therapy and its effects on peripheral artery disease (PAD) risk factors, symptoms, as well as …