The physicochemical properties of some contemporary drug candidates are moving towards
higher molecular weight, and coincidentally also higher lipophilicity in the quest for …

The absorption of orally administered drug products is a complex, dynamic process,
dependant on a range of biopharmaceutical properties; notably the aqueous solubility of a …

In oral bioavailability studies, evaluation of the absorption and transport of drugs and food
components across the intestinal barrier is crucial. Advances in the field of organ-on-a-chip …

Oral medicines represent the largest pharmaceutical market area. To achieve a therapeutic
effect, a drug must penetrate the intestinal walls, the main absorption site for orally delivered …

Drug development is an ever-growing field, increasingly requesting reliable in vitro tools to
speed up early screening phases, reducing the need for animal experiments. In oral …

Models intended to predict intestinal absorption are an essential part of the drug
development process. Although many models exist for capturing intestinal absorption, many …

Oral drug absorption is the movement of the drug from its site of administration,
gastrointestinal (GI), into the bloodstream. The oral absorption of the drug in solid dosage …

Increasing numbers of poorly water soluble drugs in development has intensified need for
bio-enabling formulations including Lipid-Based Formulations (LBF) and Solid Dispersions …

Partition and transportation of drug in the plasma membrane of a mammalian cell are the
prerequisite for its function on target protein. Therefore, comprehensive understanding of the …

There is a quest for a novel in vitro analytical methodology that is properly validated for the
prediction of human oral absorption and bioaccumulation of organic compounds with no …