Bronchiectasis—a clinical review
AE O'Donnell - New England Journal of Medicine, 2022 - Mass Medical Soc
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The lung microbiome during health and disease
K Yagi, GB Huffnagle, NW Lukacs, N Asai - International Journal of …, 2021 - mdpi.com
Healthy human lungs have traditionally been considered to be a sterile organ. However,
culture-independent molecular techniques have reported that large numbers of microbes …
culture-independent molecular techniques have reported that large numbers of microbes …
Integrative microbiomics in bronchiectasis exacerbations
M Mac Aogain, JK Narayana, PY Tiew, NABM Ali… - Nature medicine, 2021 - nature.com
Bronchiectasis, a progressive chronic airway disease, is characterized by microbial
colonization and infection. We present an approach to the multi-biome that integrates …
colonization and infection. We present an approach to the multi-biome that integrates …
European Respiratory Society guidelines for the management of adult bronchiectasis
E Polverino, PC Goeminne… - European …, 2017 - Eur Respiratory Soc
Bronchiectasis in adults is a chronic disorder associated with poor quality of life and frequent
exacerbations in many patients. There have been no previous international guidelines. The …
exacerbations in many patients. There have been no previous international guidelines. The …
Advances in bronchiectasis: endotyping, genetics, microbiome, and disease heterogeneity
Bronchiectasis is characterised by pathological dilation of the airways. More specifically, the
radiographic demonstration of airway enlargement is the common feature of a …
radiographic demonstration of airway enlargement is the common feature of a …
Bronchiectasis
JD Chalmers, AB Chang, SH Chotirmall… - Nature reviews Disease …, 2018 - nature.com
Bronchiectasis refers to abnormal dilatation of the bronchi. Airway dilatation can lead to
failure of mucus clearance and increased risk of infection. Pathophysiological mechanisms …
failure of mucus clearance and increased risk of infection. Pathophysiological mechanisms …
Neutrophil elastase activity is associated with exacerbations and lung function decline in bronchiectasis
JD Chalmers, KL Moffitt, G Suarez-Cuartin… - American journal of …, 2017 - atsjournals.org
Rationale: Sputum neutrophil elastase and serum desmosine, which is a linked marker of
endogenous elastin degradation, are possible biomarkers of disease severity and …
endogenous elastin degradation, are possible biomarkers of disease severity and …
Characterization of the “frequent exacerbator phenotype” in bronchiectasis
JD Chalmers, S Aliberti, A Filonenko… - American journal of …, 2018 - atsjournals.org
Rationale: Exacerbations are key events in the natural history of bronchiectasis, but clinical
predictors and outcomes of patients with frequently exacerbating disease are not well …
predictors and outcomes of patients with frequently exacerbating disease are not well …
Geographic variation in the aetiology, epidemiology and microbiology of bronchiectasis
Bronchiectasis is a disease associated with chronic progressive and irreversible dilatation of
the bronchi and is characterised by chronic infection and associated inflammation. The …
the bronchi and is characterised by chronic infection and associated inflammation. The …
The sputum microbiome and clinical outcomes in patients with bronchiectasis: a prospective observational study
AJ Dicker, M Lonergan, HR Keir, AH Smith… - The Lancet …, 2021 - thelancet.com
Background Infection is a key component of bronchiectasis pathophysiology.
Characterisation of the microbiome offers a higher degree of sensitivity and resolution than …
Characterisation of the microbiome offers a higher degree of sensitivity and resolution than …