[HTML][HTML] The NRF2-dependent transcriptional regulation of antioxidant defense pathways: Relevance for cell type-specific vulnerability to neurodegeneration and …
SM Boas, KL Joyce, RM Cowell - Antioxidants, 2021 - mdpi.com
Oxidative stress has been implicated in the etiology and pathobiology of various
neurodegenerative diseases. At baseline, the cells of the nervous system have the capability …
neurodegenerative diseases. At baseline, the cells of the nervous system have the capability …
[HTML][HTML] Spinal cord imaging in amyotrophic lateral sclerosis: historical concepts—novel techniques
MM El Mendili, G Querin, P Bede, PF Pradat - Frontiers in neurology, 2019 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is the most common adult onset motor neuron disease
with no effective disease modifying therapies at present. Spinal cord degeneration is a …
with no effective disease modifying therapies at present. Spinal cord degeneration is a …
Genotype-associated cerebellar profiles in ALS: focal cerebellar pathology and cerebro-cerebellar connectivity alterations
Objective Cerebellar disease burden and cerebro-cerebellar connectivity alterations are
poorly characterised in amyotrophic lateral sclerosis (ALS) despite the likely contribution of …
poorly characterised in amyotrophic lateral sclerosis (ALS) despite the likely contribution of …
Phenotypic categorisation of individual subjects with motor neuron disease based on radiological disease burden patterns: A machine-learning approach
Motor neuron disease is an umbrella term encompassing a multitude of clinically
heterogeneous phenotypes. The early and accurate categorisation of patients is hugely …
heterogeneous phenotypes. The early and accurate categorisation of patients is hugely …
[HTML][HTML] Brainstem–cortex disconnection in amyotrophic lateral sclerosis: bulbar impairment, genotype associations, asymptomatic changes and biomarker …
Background Bulbar dysfunction is a cardinal feature of ALS with important quality of life and
management implications. The objective of this study is the longitudinal evaluation of a large …
management implications. The objective of this study is the longitudinal evaluation of a large …
[HTML][HTML] Post-polio syndrome: more than just a lower motor neuron disease
S Li Hi Shing, RH Chipika, E Finegan, D Murray… - Frontiers in …, 2019 - frontiersin.org
Post-polio syndrome (PPS) is a neurological condition that affects polio survivors decades
after their initial infection. Despite its high prevalence, the etiology of PPS remains elusive …
after their initial infection. Despite its high prevalence, the etiology of PPS remains elusive …
[HTML][HTML] “Switchboard” malfunction in motor neuron diseases: Selective pathology of thalamic nuclei in amyotrophic lateral sclerosis and primary lateral sclerosis
RH Chipika, E Finegan, SLH Shing, MC McKenna… - NeuroImage: Clinical, 2020 - Elsevier
The thalamus is a key cerebral hub relaying a multitude of corticoefferent and corticoafferent
connections and mediating distinct extrapyramidal, sensory, cognitive and behavioural …
connections and mediating distinct extrapyramidal, sensory, cognitive and behavioural …
[HTML][HTML] In vitro and in vivo models of amyotrophic lateral sclerosis: an updated overview
AM Gois, DMF Mendonça, MAM Freire… - Brain Research Bulletin, 2020 - Elsevier
Abstract Amyotrophic Lateral Sclerosis (ALS) is a progressive, neurodegenerative disease
characterized by loss of upper motor neurons (UMN) and lower motor neurons (LMN) …
characterized by loss of upper motor neurons (UMN) and lower motor neurons (LMN) …
Extra-motor cerebral changes and manifestations in primary lateral sclerosis
E Finegan, SLH Shing, RH Chipika, KM Chang… - Brain imaging and …, 2021 - Springer
Primary lateral sclerosis (PLS) is classically considered a 'pure'upper motor neuron disorder.
Motor cortex atrophy and pyramidal tract degeneration are thought to be pathognomonic of …
Motor cortex atrophy and pyramidal tract degeneration are thought to be pathognomonic of …
[HTML][HTML] Brainstem pathology in amyotrophic lateral sclerosis and primary lateral sclerosis: a longitudinal neuroimaging study
Background Brainstem pathology is a hallmark feature of ALS, yet most imaging studies
focus on cortical grey matter alterations and internal capsule white matter pathology …
focus on cortical grey matter alterations and internal capsule white matter pathology …