Background Primary lateral sclerosis (PLS) is a low incidence motor neuron disease which
carries a markedly better prognosis than amyotrophic lateral sclerosis (ALS). Despite …

Amyotrophic lateral sclerosis is a relentlessly progressive multi-system condition. The
clinical picture is dominated by upper and lower motor neuron degeneration, but extra-motor …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative condition noteworthy for upper
and lower motor neuron death. Involvement of respiratory motor neuron pools leads to …

Purpose To date, research characterizing swallowing changes in individuals with
amyotrophic lateral sclerosis (ALS) has primarily relied on subjective descriptions. Thus, the …

Motor neuron diseases encompass a divergent group of conditions with considerable
differences in clinical manifestations, survival, and genetic vulnerability. One of the key …

Normal brain functioning involves the interaction of interconnected molecular and cellular
activities, which appear to alter normal to abnormal brain functioning when worsened …

Background: While amyotrophic lateral sclerosis (ALS) is widely recognised as a multi-
network disorder with extensive frontotemporal and cerebellar involvement, sensory …

Purpose: Oral diadochokinesis (DDK) is a standard dysarthria assessment task. To extract
automatic and semi-automatic DDK measurements, numerous DDK analysis algorithms …

Objective: The use of speech measures is becoming a common practice in the assessment
of bulbar disease progression in amyotrophic lateral sclerosis (ALS). This study aimed to …

The contribution of cerebellar pathology to cognitive and behavioural manifestations is
increasingly recognised, but the cerebellar profiles of FTD phenotypes are relatively poorly …