Immunogenic cell death inducing metal complexes for cancer therapy
L Zhang, N Montesdeoca, J Karges… - Angewandte Chemie …, 2023 - Wiley Online Library
Cancer is one of the deadliest diseases worldwide. Recent statistics have shown that
metastases and tumor relapse are the leading causes of cancer‐associated deaths. While …
metastases and tumor relapse are the leading causes of cancer‐associated deaths. While …
Advances in HPV‐associated tumor management: therapeutic strategies and emerging insights
With the rapid increase in the incidence of cervical cancer, anal cancer and other cancers,
human papillomavirus (HPV) infection has become a growing concern. Persistent infection …
human papillomavirus (HPV) infection has become a growing concern. Persistent infection …
Reduction of Platinum (IV) Prodrug Hemoglobin Nanoparticles with Deeply Penetrating Ultrasound Radiation for Tumor‐Targeted Therapeutically Enhanced …
G Liang, T Sadhukhan, S Banerjee… - Angewandte Chemie …, 2023 - Wiley Online Library
The development of PtIV prodrugs that are reduced into the therapeutically active PtII
species within the tumor microenvironment has received much research interest. In order to …
species within the tumor microenvironment has received much research interest. In order to …
Alendronate triggered dual‐cascade targeting prodrug nanoparticles for enhanced tumor penetration and sting activation of osteosarcoma
M Shen, Y Wang, T Bing, Y Tang… - Advanced Functional …, 2023 - Wiley Online Library
The complex physiological environment in bone tissue poses a challenge to the efficient
delivery of chemotherapeutic agents for osteosarcoma (OS) treatment; hence, an efficient …
delivery of chemotherapeutic agents for osteosarcoma (OS) treatment; hence, an efficient …
[HTML][HTML] Encapsulation of Ru (II) polypyridine complexes for tumor-targeted anticancer therapy
J Karges - BME frontiers, 2023 - spj.science.org
Ru (II) polypyridine complexes have attracted much attention as anticancer agents because
of their unique photophysical, photochemical, and biological properties. Despite their …
of their unique photophysical, photochemical, and biological properties. Despite their …
Developing a ruthenium (III) complex to trigger gasdermin E-mediated pyroptosis and an immune response based on decitabine and liposomes: Targeting inhibition of …
W Li, S Li, G Xu, X Man, T Yang, Z Zhang… - Journal of Medicinal …, 2023 - ACS Publications
To develop next-generation metal drugs with high efficiency and low toxicity for targeting
inhibition of gastric tumor growth and metastasis, we not only optimized a series of …
inhibition of gastric tumor growth and metastasis, we not only optimized a series of …
cGAS‐STING Pathway Activation and Systemic Anti‐Tumor Immunity Induction via Photodynamic Nanoparticles with Potent Toxic Platinum DNA Intercalator Against …
H Tao, J Tan, H Zhang, H Ren, Z Cai, H Liu… - Advanced …, 2023 - Wiley Online Library
The cGAS‐STING pathway, as a vital innate immune signaling pathway, has attracted
considerable attention in tumor immunotherapy research. However, STING agonists are …
considerable attention in tumor immunotherapy research. However, STING agonists are …
Simultaneous Activation of Pyroptosis and cGAS‐STING Pathway with Epigenetic/Photodynamic Nanotheranostic for Enhanced Tumor Photoimmunotherapy
F Ding, J Liu, K Ai, C Xu, X Mao, Z Liu… - Advanced …, 2024 - Wiley Online Library
Promoting innate immunity through pyroptosis induction or the cyclic GMP‐AMP synthase‐
stimulator of interferon gene (cGAS‐STING) pathway activation has emerged as a potent …
stimulator of interferon gene (cGAS‐STING) pathway activation has emerged as a potent …
Emerging platinum (IV) prodrug nanotherapeutics: A new epoch for platinum-based cancer therapy
S Zheng, G Li, J Shi, X Liu, M Li, Z He, C Tian… - Journal of Controlled …, 2023 - Elsevier
Owing to the unique DNA damaging cytotoxicity, platinum (Pt)-based chemotherapy has
long been the first-line choice for clinical oncology. Unfortunately, Pt drugs are restricted by …
long been the first-line choice for clinical oncology. Unfortunately, Pt drugs are restricted by …
[HTML][HTML] Combination of IDO inhibitors and platinum (IV) prodrugs reverses low immune responses to enhance cancer chemotherapy and immunotherapy for …
D Xiang, X Han, J Li, J Zhang, H Xiao, T Li, X Zhao… - Materials Today Bio, 2023 - Elsevier
In recent years, immune checkpoint blockades (ICBs) have made great progress in the
treatment of cancer. However, most ICBs have not yet been observed to be satisfactory in …
treatment of cancer. However, most ICBs have not yet been observed to be satisfactory in …