The cytokine storm and COVID‐19

B Hu, S Huang, L Yin - Journal of medical virology, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19), which began in Wuhan, China, in
December 2019, has caused a large global pandemic and poses a serious threat to public …

[HTML][HTML] Immunopathology of Hyperinflammation in COVID-19

JN Gustine, D Jones - The American journal of pathology, 2021 - Elsevier
The rapid spread of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome–coronavirus 2 (SARS-CoV-2), has resulted in an unprecedented …

A dynamic COVID-19 immune signature includes associations with poor prognosis

AG Laing, A Lorenc, I Del Molino Del Barrio, A Das… - Nature medicine, 2020 - nature.com
Improved understanding and management of COVID-19, a potentially life-threatening
disease, could greatly reduce the threat posed by its etiologic agent, SARS-CoV-2. Toward …

Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19

JS Lee, S Park, HW Jeong, JY Ahn, SJ Choi… - Science …, 2020 - science.org
Although most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–infected
individuals experience mild coronavirus disease 2019 (COVID-19), some patients suffer …

[HTML][HTML] Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19

YK Yeoh, T Zuo, GCY Lui, F Zhang, Q Liu, AYL Li… - Gut, 2021 - gut.bmj.com
Objective Although COVID-19 is primarily a respiratory illness, there is mounting evidence
suggesting that the GI tract is involved in this disease. We investigated whether the gut …

A single-cell atlas of the peripheral immune response in patients with severe COVID-19

AJ Wilk, A Rustagi, NQ Zhao, J Roque… - Nature medicine, 2020 - nature.com
There is an urgent need to better understand the pathophysiology of Coronavirus disease
2019 (COVID-19), the global pandemic caused by SARS-CoV-2, which has infected more …

Immune response, inflammation, and the clinical spectrum of COVID-19

LF García - Frontiers in immunology, 2020 - frontiersin.org
The current COVID-19 pandemic began in December 2019 in Wuhan (China) and rapidly
extended to become a global sanitary and economic emergency. Its etiological agent is the …

Covid-19 image data collection: Prospective predictions are the future

JP Cohen, P Morrison, L Dao, K Roth… - arXiv preprint arXiv …, 2020 - arxiv.org
Across the world's coronavirus disease 2019 (COVID-19) hot spots, the need to streamline
patient diagnosis and management has become more pressing than ever. As one of the …

Syncytia formation by SARS‐CoV‐2‐infected cells

J Buchrieser, J Dufloo, M Hubert, B Monel… - The EMBO …, 2020 - embopress.org
Severe cases of COVID‐19 are associated with extensive lung damage and the presence of
infected multinucleated syncytial pneumocytes. The viral and cellular mechanisms …

Severe COVID-19 is marked by a dysregulated myeloid cell compartment

J Schulte-Schrepping, N Reusch, D Paclik, K Baßler… - Cell, 2020 - cell.com
Summary Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract
infection, however, a subset of patients progress to severe disease and respiratory failure …