Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …

Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …

Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

Following acute kidney injury (AKI), renal tubular cells may stimulate fibroblasts in a
paracrine fashion leading to interstitial fibrosis, but the paracrine factors and their regulation …

There is increasing evidence that skin aging is significantly enforced by the accumulation of
senescent dermal fibroblasts. Various stressors damaging macromolecules inside and …

Idiopathic pulmonary fibrosis (IPF) is a fatal age-associated disease that is characterized by
progressive and irreversible scarring of the lung. The pathogenesis of IPF is not completely …

Summary Type 1 diabetes (T1D) is an organ-specific autoimmune disease characterized by
hyperglycemia due to progressive loss of pancreatic beta cells. Immune-mediated beta cell …

Human mesenchymal stem cells (MSCs) are primary multipotent cells capable of
differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under …

Cellular senescence occurs in proliferating cells as a consequence of various triggers
including telomere shortening, DNA damage, and inappropriate expression of oncogenes …