Introduction: The progesterone receptor plays an essential role in uterine physiology and
reproduction. Selective progesterone receptor modulators (SPRMs) have emerged as a …

Mifepristone (RU486) is a born‐for‐woman molecule discovered three decades ago. Unlike
those antihypertensive and antipsychotic pharmaceutical blockbusters, this abortifacient …

OBJECTIVE: To discuss the mechanism of action of selective progesterone receptor
modulators (SPRMs) and summarize the preclinical and clinical efficacy and safety data …

Abstract Background Interleukin (IL)-6 (mainly of tumor origin) activates glutathione (GSH)
release from hepatocytes and its interorgan transport to B16-F10 melanoma metastatic foci …

Clostridium sordellii and Clostridium difficile are closely related anaerobic Gram-positive,
spore-forming human pathogens. C. sordellii and C. difficile form spores that are believed to …

Nowadays, unwanted pregnancy is a major globe tragedy for millions of women, associated
with significant direct and indirect costs, no matter for individuals or society. The …

目的: 评价米非司酮与妈富隆治疗围绝经期功能失调性子宫出血的临床疗效. 方法:
将围绝经期功能失调性子宫出血患者120 例随机分为米非司酮组和妈富隆组, 治疗随访3 个月 …

Endometriosis is an inflammatory estrogen-dependent disease defined by the presence of
endometrial glands and stroma at extrauterine sites. The main purpose of endometriosis …

Importance Adenomyosis is a common chronic gynecological disorder, and its treatment is
an unmet need. New therapies need to be developed. Mifepristone is being tested for …

Background Lung cancer is the leading cause of cancer deaths in the world. The major
histopathological subtype of lung cancer is non-small cell lung cancer (NSCLC). Platinum …