At least 150 human proteins are glycosylphosphatidylinositol-anchored proteins (GPI-APs).
The protein moiety of GPI-APs lacking transmembrane domains is anchored to the plasma …

Protein traffic is of critical importance for normal cellular physiology. In eukaryotes, spherical
transport vesicles move proteins and lipids from one internal membrane-bound …

Glycosylphosphatidylinositols (GPIs) act as membrane anchors of many eukaryotic cell
surface proteins. GPIs in various organisms have a common backbone consisting of …

Transport of newly synthesized proteins from the endoplasmic reticulum (ER) to the Golgi
complex is highly selective. As a general rule, such transport is limited to soluble and …

Protein sorting in the secretory pathway is crucial to maintain cellular compartmentalization
and homeostasis. In addition to coat-mediated sorting, the role of lipids in driving protein …

Sphingolipids play important roles in physiology and cell biology, but a systematic
examination of their functions is lacking. We performed a genome-wide CRISPRi screen in …

Abstract p24 family proteins have been known for a long time, but their functions have
remained elusive. However, they are emerging as essential regulators of protein trafficking …

In eukaryotes, many cell surface proteins are attached to the plasma membrane via a
glycolipid glycosylphosphatidylinositol (GPI) anchor. GPI-anchored proteins (GPI-APs) …

Maintaining the optimal performance of cell processes and organelles is the task of auto-
regulatory systems. Here we describe an auto-regulatory device that helps to maintain …

Glycosylphosphatidylinositol (GPI) is a glycolipid added to the C-terminus of a large variety
of proteins in eukaryotes, thereby anchoring these proteins to the cell surface. More than …