As many as one in 20 people in Europe and North America have some form of autoimmune
disease. These diseases arise in genetically predisposed individuals but require an …

A relationship between viral infections and the simultaneous or subsequent development of
drug rashes has been observed in a number of clinical situations. We have recently …

Little is known about the processing of putative human autoantigens and why tolerance is
established to some T cell epitopes but not others. Here we show that a principal human …

Multiple sclerosis (MS) is a complex chronic disease with an unknown etiology. It is
considered an inflammatory demyelinating and neurodegenerative disorder of the central …

The immune system must avoid aggressive T-cell responses against self-antigens. But,
paradoxically, exposure to self-peptides seems to have an important role in positive …

Stroke-induced immunodepression (SIDS) is an essential cause of poststroke infections.
Pharmacological inhibition of SIDS appears promising in preventing life-threatening …

After stroke, the blood–brain barrier is transiently disrupted, allowing leukocytes to enter the
brain and brain antigens to enter the peripheral circulation. This encounter of normally …

Although the complete picture for alopecia areata (AA) pathogenesis has yet to be
determined, recent research has made much progress in our understanding of the disease …

Autoimmune diseases affect as many as 1 in 10 people in Europe and North America.
Although the prevalence of most diseases is quite low, their individual incidence has greatly …

Infections sometimes associate with exacerbations of autoimmune diseases through
pathways that are poorly understood. Ag-specific mechanisms such as cross-reactivity …