Drug distribution into the brain is strictly regulated by the presence of the blood–brain barrier
(BBB) that is formed by brain capillary endothelial cells. Since the endothelial cells are …

O-(2-[18F] fluoroethyl)-l-tyrosine (FET) is a promising tracer for PET that has demonstrated
convincing results especially in the diagnostics of brain tumors. In contrast to other …

Abstract System L‐type transport of large neutral amino acids is mediated by ubiquitous
LAT1‐4F2hc and epithelial LAT2‐4F2hc. These heterodimers are thought to function as …

Adaptive immunity, a vertebrate specialization, adds memory and exquisite specificity to the
basic innate immune responses present in invertebrates while conserving metabolic …

Heterodimeric amino acid transporters are comprised of two subunits, a polytopic membrane
protein (light chain) and an associated type II membrane protein (heavy chain). The heavy …

The plasma membrane transport system L is in many cells the only (efficient) pathway for the
import of large branched and aromatic neutral amino acids. The corresponding transporters …

Amino acid homeostasis is maintained by import, export, oxidation, and synthesis of
nonessential amino acids, and by the synthesis and breakdown of protein. These processes …

Cystinuria (MIM 220100) is a common recessive disorder of renal reabsorption of cystine
and dibasic amino acids. Mutations in SLC3A1, encoding rBAT, cause cystinuria type I (ref …

To find reliable biomarkers for high‐grade malignancy, the relationship between
immunohistochemical L‐type amino‐acid transporter 1 (LAT1) expression of biopsy …

A cDNA was isolated from the mouse brain that encodes a novel Na+-independent neutral
amino acid transporter. The encoded protein, designated as Asc-1 (asc-type amino acid …