Amino acid transport across the human placenta is active, mediated by specific transporters
in syncytiotrophoblast plasma membranes. Using functional criteria such as substrate …

System L amino acid transporters mediate the movement of bulky neutral amino acids
across cell membranes. Until now three proteins that induce system L activity have been …

Methylmercury (MeHg) readily crosses cell membrane barriers to reach its target tissue, the
brain. Although it is generally assumed that this rapid transport is due to simple diffusion …

Alterations in placental transport may contribute to accelerated fetal growth in pregnancies
complicated by diabetes. We studied the activity of the syncytiotrophoblast amino acid …

Glutamine is the preferred precursor for the neurotransmitter pool of glutamate, the major
excitatory transmitter in the mammalian central nervous system. We have isolated a …

Because of the physiological nature of the blood-brain barrier (BBB), transport of chemical
compounds between blood and brain has been widely believed to occur by means of …

Much has been learned about plasma membrane glutamine transporter activities in health
and disease over the past 30 years, including their potential regulatory role in metabolism …

A cDNA that encodes a novel Na+-independent neutral amino acid transporter was isolated
from FLC4 human hepatocarcinoma cells by expression cloning. When expressed in …

Positron emission tomography (PET) using l-[methyl-11 C]-methionine (MET) is the most
popular amino acid imaging modality in oncology, although its use is restricted to PET …

The heteromeric amino acid transporters (HATs) are composed of two polypeptides: a heavy
subunit (HSHAT) and a light subunit (LSHAT) linked by a disulfide bridge. HSHATs are N …