Mammalian cells rely on cellular uptake of the essential amino acid tryptophan. Tryptophan
sequestration by up-regulation of the key enzyme for tryptophan degradation, indoleamine …

Abstract Background System L transporters LAT1 (SLC7A5) and LAT2 (SLC7A8) mediate
the uptake of large, neutral amino acids in the human placenta. Many System L substrates …

Key points• Fetal growth is positively correlated to maternal adiposity, but the underlying
mechanisms remain largely unknown.• Maternal circulating levels of adiponectin, a hormone …

The heteromeric amino acid transporters are composed of a type II glycoprotein and a non‐
glycosylated polytopic membrane protein. System bo,+ exchanges dibasic for neutral amino …

Cystinuria (OMIM 220100) is a common recessive disorder of renal reabsorption of cystine
and dibasic amino acids that results in nephrolithiasis of cystine. Mutations in SLC3A1 …

Solute carriers form one of three major superfamilies of membrane transporters in humans,
and include uniporters, exchangers and symporters. Following several decades of …

While many of the genes and molecular pathways in the germinal center B cell response
which initiate protective antibody production are known, the contributions of individual …

The feto-placental unit relies on a maternal supply of indispensable amino acids and
iodothyronines for early development and normal growth. We examined the role of the …

The pathophysiology of age‐related hearing loss (ARHL), or presbycusis, involves a
complex interplay between environmental and genetic factors. The fundamental …

Background and aims Molecular target therapy against L-type amino acid transporter 1
(LAT1) is unique and expected to be developed soon. LAT1 expression was investigated in …