The endocannabinoid signalling system was discovered because receptors in this system
are the targets of compounds present in psychotropic preparations of Cannabis sativa. The …

Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

First isolated from Cannabis in 1940 by Roger Adams, the structure of CBD was not
completely elucidated until 1963. Subsequent studies resulted in the pronouncement that …

Cannabidiol (CBD) is a non-psychotomimetic phytocannabinoid derived from Cannabis
sativa. It has possible therapeutic effects over a broad range of neuropsychiatric disorders …

Background: Numerous physical, psychological, and emotional benefits have been
attributed to marijuana since its first reported use in 2,600 BC in a Chinese pharmacopoeia …

The endocannabinoid system (ECS) is composed of two G protein-coupled receptors
(GPCRs), the cannabinoid CB1 and CB2 receptors, and the two main endogenous lipid …

The identification and cloning of the two major cannabinoid (CB1 and CB2) receptors
together with the discovery of their endogenous ligands in the late 80s and early 90s …

Cannabidiol (CBD) is a phytocannabinoid with therapeutic properties for numerous
disorders exerted through molecular mechanisms that are yet to be completely identified …

Movement disorders such as Parkinson's disease and dyskinesia are highly debilitating
conditions linked to oxidative stress and neurodegeneration. When available, the …

Currently, the concept of 'neuroinflammation'includes inflammation associated with
neurodegenerative diseases, in which there is little or no infiltration of blood-derived …