eTRANSAFE: data science to empower translational safety assessment Skip to main content
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Historical data from control groups in animal toxicity studies are currently mainly used for
comparative purposes to assess validity and robustness of study results. Due to the highly …

Although biomedical research is experiencing a data explosion, the accumulation of vast
quantities of data alone does not guarantee a primary objective for science: building upon …

The availability of large amounts of high-quality control data from tightly controlled regulated
animal safety data has created the idea to re-use these data beyond its classical …

Propylthiouracil (PTU) and methimazole (MMI), two classical antithyroid agents possess risk
of drug-induced liver injury (DILI) with unknown mechanism of action. This study aimed to …

Undisturbed home cage recording of mouse activity and behavior has received increasing
attention in recent years. In parallel, several technologies have been developed in a bid to …

The replacement of a proportion of concurrent controls by virtual controls in nonclinical
safety studies has gained traction over the last few years. This is supported by foundational …

While the first use of the term “Predictive Toxicology” was mainly focusing on in silico
approaches and applied almost synonymously to computational toxicology (Helma, 2005) it …