The recent genomic characterization of cancers has revealed recurrent somatic point
mutations and copy number changes affecting genes encoding RNA splicing factors. Initial …

Stress proteins (SPs) including heat-shock proteins (HSPs), RNA chaperones, and ER
associated stress proteins are molecular chaperones essential for cellular homeostasis. The …

Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …

RNA-binding proteins control many aspects of cellular biology through binding single-
stranded RNA binding motifs (RBMs),,. However, RBMs can be buried within their local RNA …

Human papillomaviruses (HPV) are a group of small non-enveloped DNA viruses whose
infection causes benign tumors or cancers. HPV16 and HPV18, the two most common high …

An inducible program of inflammatory gene expression is central to antimicrobial defenses.
This response is controlled by a collaboration involving signal-dependent activation of …

Transactive response DNA-binding protein-43 (TDP-43) is an RNA/DNA binding protein that
forms phosphorylated and ubiquitinated aggregates in the cytoplasm of motor neurons in …

RNase H1-dependent antisense oligonucleotides (ASOs) are active in reducing levels of
both cytoplasmic mRNAs and nuclear retained RNAs. Although ASO activity in the nucleus …

▪ Abstract Alternative pre-mRNA splicing is a central mode of genetic regulation in higher
eukaryotes. Variability in splicing patterns is a major source of protein diversity from the …

The biochemical basis for the regulation of fibre-type determination in skeletal muscle is not
well understood. In addition to the expression of particular myofibrillar proteins, type I (slow …