The management of orofacial pain to alleviate the quality of life of affected patients is
becoming increasingly challenging for scientific research and healthcare professionals …

Aim To provide an overview of mechanisms underlying craniofacial pain; to highlight
peripheral and central adaptations that may promote chronification of pain in craniofacial …

Introduction The trigeminal ganglion is unique among the somatosensory ganglia regarding
its topography, structure, composition and possibly some functional properties of its cellular …

The trigeminal ganglion with its three trigeminal nerve tracts consists mainly of clusters of
sensory neurons with their peripheral and central processes. Most neurons are surrounded …

The activation of the satellite glial cells (SGCs) surrounding the dorsal root ganglion (DRG)
neurons appears to play a role in pathological pain. We tested the hypothesis that …

There is a brief summary of the background literature about purinergic signalling. The review
then considers purinergic mechanosensory transduction involved in visceral, cutaneous and …

Background Microglial activation contributes to the development of chronic migraine (CM).
The P2Y12 receptor (P2Y12R), a metabolic purinoceptor that is expressed on microglia in …

Temporomandibular joint disorders (TMD) are a common health condition caused by the
structural or functional disorders of masticatory muscles and the temporomandibular joint …

Orofacial pain is a universal predicament, afflicting millions of individuals worldwide.
Research on the molecular mechanisms of orofacial pain has predominately focused on the …

Satellite glial cells (SGCs) surrounding the neuronal somas in peripheral sensory ganglia
are sensitive to neuronal stressors, which induce their reactive state. It is believed that such …