Treatment strategies for cryptococcal infection: challenges, advances and future outlook

KR Iyer, NM Revie, C Fu, N Robbins… - Nature Reviews …, 2021 - nature.com
Cryptococcus spp., in particular Cryptococcus neoformans and Cryptococcus gattii, have an
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …

[HTML][HTML] Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex

F Hagen, K Khayhan, B Theelen, A Kolecka… - Fungal genetics and …, 2015 - Elsevier
Phylogenetic analysis of 11 genetic loci and results from many genotyping studies revealed
significant genetic diversity with the pathogenic Cryptococcus gattii/Cryptococcus …

Improved prediction of fungal effector proteins from secretomes with EffectorP 2.0

J Sperschneider, PN Dodds… - Molecular plant …, 2018 - Wiley Online Library
Plant‐pathogenic fungi secrete effector proteins to facilitate infection. We describe extensive
improvements to EffectorP, the first machine learning classifier for fungal effector prediction …

Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis

KJ Kwon-Chung, JA Fraser… - Cold Spring …, 2014 - perspectivesinmedicine.cshlp.org
Cryptococcus neoformans and Cryptococcus gattii are the two etiologic agents of
cryptococcosis. They belong to the phylum Basidiomycota and can be readily distinguished …

EffectorP: predicting fungal effector proteins from secretomes using machine learning

J Sperschneider, DM Gardiner, PN Dodds… - New …, 2016 - Wiley Online Library
Eukaryotic filamentous plant pathogens secrete effector proteins that modulate the host cell
to facilitate infection. Computational effector candidate identification and subsequent …

Fungi that infect humans

JR Köhler, B Hube, R Puccia, A Casadevall… - Microbiology …, 2017 - Am Soc Microbiol
Fungi must meet four criteria to infect humans: growth at human body temperatures,
circumvention or penetration of surface barriers, lysis and absorption of tissue, and …

[HTML][HTML] Cryptococcosis diagnosis and treatment: What do we know now

JR Perfect, T Bicanic - Fungal Genetics and Biology, 2015 - Elsevier
Cryptococcosis has evolved into a major invasive fungal disease over the last century. Its
primary epidemiology has been focused on three major outbreaks of disease that reflects …

ApoplastP: prediction of effectors and plant proteins in the apoplast using machine learning

J Sperschneider, PN Dodds, KB Singh… - New …, 2018 - Wiley Online Library
The plant apoplast is integral to intercellular signalling, transport and plant–pathogen
interactions. Plant pathogens deliver effectors both into the apoplast and inside host cells …

Studying fungal pathogens of humans and fungal infections: Fungal diversity and diversity of approaches

G Janbon, J Quintin, F Lanternier, C d'Enfert - Microbes and Infection, 2019 - Elsevier
Abstract Seminal work by Louis Pasteur revealed the contribution of fungi–yeasts and
microsporidia to agroindustry and disease in animals, respectively. More than 150 years …

Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans

CA Desjardins, C Giamberardino, SM Sykes… - Genome …, 2017 - genome.cshlp.org
Cryptococcus neoformans is an opportunistic fungal pathogen that causes approximately
625,000 deaths per year from nervous system infections. Here, we leveraged a unique …