Treatment strategies for cryptococcal infection: challenges, advances and future outlook
Cryptococcus spp., in particular Cryptococcus neoformans and Cryptococcus gattii, have an
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …
[HTML][HTML] Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex
Phylogenetic analysis of 11 genetic loci and results from many genotyping studies revealed
significant genetic diversity with the pathogenic Cryptococcus gattii/Cryptococcus …
significant genetic diversity with the pathogenic Cryptococcus gattii/Cryptococcus …
Improved prediction of fungal effector proteins from secretomes with EffectorP 2.0
J Sperschneider, PN Dodds… - Molecular plant …, 2018 - Wiley Online Library
Plant‐pathogenic fungi secrete effector proteins to facilitate infection. We describe extensive
improvements to EffectorP, the first machine learning classifier for fungal effector prediction …
improvements to EffectorP, the first machine learning classifier for fungal effector prediction …
Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis
KJ Kwon-Chung, JA Fraser… - Cold Spring …, 2014 - perspectivesinmedicine.cshlp.org
Cryptococcus neoformans and Cryptococcus gattii are the two etiologic agents of
cryptococcosis. They belong to the phylum Basidiomycota and can be readily distinguished …
cryptococcosis. They belong to the phylum Basidiomycota and can be readily distinguished …
EffectorP: predicting fungal effector proteins from secretomes using machine learning
Eukaryotic filamentous plant pathogens secrete effector proteins that modulate the host cell
to facilitate infection. Computational effector candidate identification and subsequent …
to facilitate infection. Computational effector candidate identification and subsequent …
Fungi that infect humans
Fungi must meet four criteria to infect humans: growth at human body temperatures,
circumvention or penetration of surface barriers, lysis and absorption of tissue, and …
circumvention or penetration of surface barriers, lysis and absorption of tissue, and …
[HTML][HTML] Cryptococcosis diagnosis and treatment: What do we know now
JR Perfect, T Bicanic - Fungal Genetics and Biology, 2015 - Elsevier
Cryptococcosis has evolved into a major invasive fungal disease over the last century. Its
primary epidemiology has been focused on three major outbreaks of disease that reflects …
primary epidemiology has been focused on three major outbreaks of disease that reflects …
ApoplastP: prediction of effectors and plant proteins in the apoplast using machine learning
J Sperschneider, PN Dodds, KB Singh… - New …, 2018 - Wiley Online Library
The plant apoplast is integral to intercellular signalling, transport and plant–pathogen
interactions. Plant pathogens deliver effectors both into the apoplast and inside host cells …
interactions. Plant pathogens deliver effectors both into the apoplast and inside host cells …
Studying fungal pathogens of humans and fungal infections: Fungal diversity and diversity of approaches
G Janbon, J Quintin, F Lanternier, C d'Enfert - Microbes and Infection, 2019 - Elsevier
Abstract Seminal work by Louis Pasteur revealed the contribution of fungi–yeasts and
microsporidia to agroindustry and disease in animals, respectively. More than 150 years …
microsporidia to agroindustry and disease in animals, respectively. More than 150 years …
Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans
CA Desjardins, C Giamberardino, SM Sykes… - Genome …, 2017 - genome.cshlp.org
Cryptococcus neoformans is an opportunistic fungal pathogen that causes approximately
625,000 deaths per year from nervous system infections. Here, we leveraged a unique …
625,000 deaths per year from nervous system infections. Here, we leveraged a unique …