Acute pancreatitis is a common indication for hospital admission, increasing in incidence,
including in children, pregnancy and the elderly. Moderately severe acute pancreatitis with …

Importance Chronic pancreatitis (CP) is a chronic inflammatory and fibrotic disease of the
pancreas with a prevalence of 42 to 73 per 100 000 adults in the United States …

Acute lung injury (ALI) is a complication of severe acute pancreatitis (SAP). Sitagliptin (SIT)
is a DPP4 inhibitor that exerts anti-inflammatory and antioxidant effects; however, its …

Background: Severe acute pancreatitis (AP) continues to be a serious gastrointestinal
disease with relevant morbidity and mortality. Summary: Successful clinical management …

Long known as digestive organelles, lysosomes have now emerged as multifaceted centers
responsible for degradation, nutrient sensing, and immunity. Growing evidence also …

Macrophages play a crucial role in the pathogenesis of pancreatitis that is a common
gastrointestinal disease. Particularly, macrophages differentiate into different phenotypes …

Chronic pancreatitis is a multifactorial, fibroinflammatory syndrome in which repetitive
episodes of pancreatic inflammation lead to extensive fibrotic tissue replacement, resulting …

Abstract Background The American College of Medical Genetics and Genomics (ACMG)-
recommended five variant classification categories (pathogenic, likely pathogenic, uncertain …

Background and Purpose Gut microbiota dysbiosis induced by acute pancreatitis (AP)
exacerbates pancreatic injury and systemic inflammatory responses. The alleviation of gut …

Chronic pancreatitis (CP) is characterized by chronic inflammation and the progressive
fibrotic replacement of exocrine and endocrine pancreatic tissue. We identify Treg cells as …