[HTML][HTML] Fighting antibiotic resistance in hospital-acquired infections: current state and emerging technologies in disease prevention, diagnostics and therapy

E Avershina, V Shapovalova, G Shipulin - Frontiers in microbiology, 2021 - frontiersin.org
Rising antibiotic resistance is a global threat that is projected to cause more deaths than all
cancers combined by 2050. In this review, we set to summarize the current state of antibiotic …

Anti-viral triterpenes: a review

P Darshani, S Sen Sarma, AK Srivastava… - Phytochemistry …, 2022 - Springer
Triterpenes are naturally occurring derivatives biosynthesized following the isoprene rule of
Ruzicka. The triterpenes have been reported to possess a wide range of therapeutic …

Targeting nucleotide metabolism as the nexus of viral infections, cancer, and the immune response

Y Ariav, JH Ch'ng, HR Christofk, N Ron-Harel… - Science advances, 2021 - science.org
Virus-infected cells and cancers share metabolic commonalities that stem from their
insatiable need to replicate while evading the host immune system. These similarities …

Advances and perspectives in the management of varicella-zoster virus infections

G Andrei, R Snoeck - Molecules, 2021 - mdpi.com
Varicella-zoster virus (VZV), a common and ubiquitous human-restricted pathogen, causes a
primary infection (varicella or chickenpox) followed by establishment of latency in sensory …

40 years after the registration of acyclovir: do we need new anti-herpetic drugs?

A Majewska, B Mlynarczyk-Bonikowska - International journal of …, 2022 - mdpi.com
Herpes simplex virus types 1 and 2 HSV1 and 2, namely varicella-zoster VZV and
cytomegalovirus CMV, are among the most common pathogens worldwide. They remain in …

[HTML][HTML] EBV-associated diseases: Current therapeutics and emerging technologies

S Chakravorty, B Afzali, M Kazemian - Frontiers in Immunology, 2022 - frontiersin.org
EBV is a prevalent virus, infecting> 90% of the world's population. This is an oncogenic virus
that causes~ 200,000 cancer-related deaths annually. It is, in addition, a significant …

Viral G-quadruplexes: New frontiers in virus pathogenesis and antiviral therapy

E Ruggiero, SN Richter - Annual reports in medicinal chemistry, 2020 - Elsevier
Viruses are the most abundant organisms on our planet, affecting all living beings: some of
them are responsible for massive epidemics that concern health, national economies and …

Novel therapeutics for Epstein–Barr virus

G Andrei, E Trompet, R Snoeck - Molecules, 2019 - mdpi.com
Epstein–Barr virus (EBV) is a human γ-herpesvirus that infects up to 95% of the adult
population. Primary EBV infection usually occurs during childhood and is generally …

[HTML][HTML] Current antivirals and novel botanical molecules interfering with herpes simplex virus infection

DM Álvarez, E Castillo, LF Duarte, J Arriagada… - Frontiers in …, 2020 - frontiersin.org
Herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) are highly prevalent within the
human population and are characterized by lifelong infections and sporadic recurrences …

Advances in antiviral delivery systems and chitosan-based polymeric and nanoparticulate antivirals and antiviral carriers

D Žigrayová, V Mikušová, P Mikuš - Viruses, 2023 - mdpi.com
Current antiviral therapy research is focused on developing dosage forms that enable highly
effective drug delivery, providing a selective effect in the organism, lower risk of adverse …