DNA functional materials assembled from branched DNA: design, synthesis, and applications

Y Dong, C Yao, Y Zhu, L Yang, D Luo… - Chemical Reviews, 2020 - ACS Publications
DNA is traditionally known as a central genetic biomolecule in living systems. From an
alternative perspective, DNA is a versatile molecular building-block for the construction of …

The crosstalk between microbiome and asthma: exploring associations and challenges

MI Abdel‐Aziz, SJH Vijverberg… - Clinical & …, 2019 - Wiley Online Library
With the advancement of high‐throughput DNA/RNA sequencing and computational
analysis techniques, commensal bacteria are now considered almost as important as …

Addressing the in vivo delivery of nucleic-acid nanostructure therapeutics

S Alexander, MG Moghadam, M Rothenbroker… - Advanced Drug Delivery …, 2023 - Elsevier
DNA and RNA nanostructures are being investigated as therapeutics, vaccines, and drug
delivery systems. These nanostructures can be functionalized with guests ranging from …

Emerging nanoparticle platforms for CpG oligonucleotide delivery

M Li, H Yao, K Yi, YH Lao, D Shao, Y Tao - Biomaterials Science, 2024 - pubs.rsc.org
Unmethylated cytosine–phosphate–guanine (CpG) oligodeoxynucleotides (ODNs), which
were therapeutic DNA with high immunostimulatory activity, have been applied in …

A dual macrophage targeting nanovector for delivery of oligodeoxynucleotides to overcome cancer-associated immunosuppression

XY He, BY Liu, JL Wu, SL Ai, RX Zhuo… - ACS applied materials …, 2017 - ACS Publications
To overcome cancer-associated immunosuppression, we prepared a dual-targeting vector
to deliver CpG oligodeoxynucleotides (ODN) to macrophages. The dual-targeting system …

Prospective cancer therapies using stimuli‐responsive DNA nanostructures

I Seitz, A Shaukat, K Nurmi, H Ijäs… - Macromolecular …, 2021 - Wiley Online Library
Nanostructures based on DNA self‐assembly present an innovative way to address the
increasing need for target‐specific delivery of therapeutic molecules. Currently, most of the …

Growing prospects of DNA nanomaterials in novel biomedical applications

Z Suo, J Chen, X Hou, Z Hu, F Xing, L Feng - RSC advances, 2019 - pubs.rsc.org
As an important genetic material for life, DNA has been investigated widely in recent years,
especially in interdisciplinary fields crossing nanomaterials and biomedical applications. It …

Nanoparticle-based CpG-oligonucleotide therapy for treating allergic asthma

BE Givens, SM Geary, AK Salem - Immunotherapy, 2018 - Taylor & Francis
Allergic asthma is becoming increasingly prevalent in the developed world, and many
common allergens are capable of inducing allergic asthma responses, particularly in atopic …

Macrophage-Targeting DNA Nanomaterials: A Future Direction of Biological Therapy

YC Tu, YM Wang, LJ Yao - International Journal of Nanomedicine, 2024 - Taylor & Francis
DNA can be used for precise construction of complex and flexible micro-nanostructures,
including DNA origami, frame nucleic acids, and DNA hydrogels. DNA nanomaterials have …

Targeted delivery of immunostimulatory CpG oligodeoxynucleotides to antigen-presenting cells in draining lymph nodes by stearic acid modification and …

M Nagaoka, W Liao, K Kusamori… - International journal of …, 2022 - mdpi.com
Polypod-like structured nucleic acids (polypodnas), which are nanostructured DNAs, are
useful for delivering cytosine-phosphate guanine oligodeoxynucleotides (CpG ODNs) to …