Thiazole ring—A biologically active scaffold

A Petrou, M Fesatidou, A Geronikaki - Molecules, 2021 - mdpi.com
Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …

Review of the synthesis and biological activity of thiazoles

SH Ali, AR Sayed - Synthetic Communications, 2021 - Taylor & Francis
This study covers the literature documents available on the chemistry of preparation of
thiazoles. Additionally, we cover the biological activities of certain thiazoles. The information …

An overview of the synthesis and antimicrobial, antiprotozoal, and antitumor activity of thiazole and bisthiazole derivatives

AM Borcea, I Ionuț, O Crișan, O Oniga - Molecules, 2021 - mdpi.com
Thiazole, a five-membered heteroaromatic ring, is an important scaffold of a large number of
synthetic compounds. Its diverse pharmacological activity is reflected in many clinically …

QSAR, molecular docking and ADMET properties in silico studies of novel 4, 5, 6, 7-tetrahydrobenzo [D]-thiazol-2-Yl derivatives derived from dimedone as potent anti …

O Daoui, S Elkhattabi, S Chtita, R Elkhalabi, H Zgou… - Heliyon, 2021 - cell.com
A quantitative structure-activity relationship (QSAR) study is performed on 48 novel 4, 5, 6, 7-
tetrahydrobenzo [D]-thiazol-2 derivatives as anticancer agents capable of inhibiting c-Met …

Synthesis, anticancer activity and mechanism of action of new thiazole derivatives

TI de Santana, M de Oliveira Barbosa… - European journal of …, 2018 - Elsevier
Thiazole derivatives are recognized to possess various biological activities as antiparasitic,
antifungal, antimicrobial and antiproliferative. The present work reports the synthesis of 22 …

Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: A decade update

K Laxmikeshav, P Kumari… - Medicinal Research …, 2022 - Wiley Online Library
This review article proposes a comprehensive report of the design strategies engaged in the
development of various sulfur‐bearing cytotoxic agents. The outcomes of various studies …

New series of thiazole derivatives: synthesis, structural elucidation, antimicrobial activity, molecular modeling and MOE docking

I Althagafi, N El-Metwaly, TA Farghaly - Molecules, 2019 - mdpi.com
Based on the extensive biological activities of thiazole derivatives against different types of
diseases, we are interested in the effective part of many natural compounds, so we …

Hydrazonoyl bromide precursors as DHFR inhibitors for the synthesis of bis-thiazolyl pyrazole derivatives; antimicrobial activities, antibiofilm, and drug combination …

SA Ibrahim, EA Fayed, HF Rizk, SE Desouky… - Bioorganic …, 2021 - Elsevier
Microbial resistance is a big concern worldwide, making the development of new
antimicrobial drugs difficult. The thiazole and pyrazole rings are important heterocyclic …

[HTML][HTML] Antiproliferative activity of thiazole and oxazole derivatives: A systematic review of in vitro and in vivo studies

NY Guerrero-Pepinosa, MC Cardona-Trujillo… - Biomedicine & …, 2021 - Elsevier
Thiazole and oxazole are compounds with a heterocyclic nucleus that have attracted the
attention of medicinal chemistry due to the great variety of biological activities that they …

A caryophyllene oxide and other potential anticholinesterase and anticancer agent in Salvia verticillata subsp. amasiaca (Freyn & Bornm.) Bornm. (Lamiaceae)

S Karakaya, SV Yilmaz, Ö Özdemir… - Journal of Essential …, 2020 - Taylor & Francis
In vitro cholinesterase inhibition, antioxidant and anticancer potentials of the essential oils
and extracts of flowers and aerial parts of Salvia verticillata subsp. amasiaca have been …