Abstract The Precision Medicine Initiative is an NCI driven program in cancer to generate the
scientific evidence needed to move the concept of precision medicine into clinical practice …

Drug resistance is one of the major problems in targeted cancer therapy. A major cause of
resistance is changes in the amino acids that form the drug-target binding site. Despite of the …

We describe the development, optimization, and validation of 384-well growth inhibition
assays for six patient-derived melanoma cell lines (PDMCLs), three wild type (WT) for BRAF …

Therapeutic failures in cancer therapy are often associated with metabolic plasticity. The use
of metabolic modulators as anti-cancer agents has been effective in correcting metabolic …

BRAF is mutated at a high frequency in various malignancies, including melanoma, papillary
thyroid carcinoma and colorectal adenocarcinoma. BRAF is an element of the …

Pancreatic-type ribonucleases (ptRNases) are prevalent secretory enzymes that catalyze
the cleavage of RNA. Ribonuclease inhibitor (RI) is a cytosolic protein that has femtomolar …

Rheumatoid arthritis (RA), one of the most common chronic inflammatory diseases, is an
autoimmune disease that causes cartilage, bone damage, and disability. RA has become a …

Mutacje w BRAF bardzo często występują w wielu typach nowotworów, m. in. w czerniaku,
raku brodawkowatym tarczycy i raku jelita grubego. BRAF jest elementem szlaku …

abstract Over the decades, the exploitation of medicinal plants has been done by numerous
merchandise companies or dealers through various conventional healers in a way to lessen …

Despite increasing amounts of experimental evidence depicting the involvement of non-
coding RNAs in cancer, the study of BRAFV600E-regulated genes has thus far focused …