Inflammasome and its therapeutic targeting in rheumatoid arthritis

Q Jiang, X Wang, E Huang, Q Wang, C Wen… - Frontiers in …, 2022 - frontiersin.org
Inflammasome is a cytoplasmic multiprotein complex that facilitates the clearance of
exogenous microorganisms or the recognition of endogenous danger signals, which is …

Moxibustion regulates the polarization of macrophages through the IL-4/STAT6 pathway in rheumatoid arthritis

Y Zhong, L Zhang, W Lu, Y Shang, H Zhou - Cytokine, 2022 - Elsevier
Objective To observe the effects of moxibustion on “Shenshu” and “Zusanli” on macrophage
polarization and IL-4/STAT6 signaling pathway in rats with rheumatoid arthritis (RA). To …

Artemisitene suppresses rheumatoid arthritis progression via modulating METTL3‐mediated N6‐methyladenosine modification of ICAM2 mRNA in fibroblast‐like …

J Chen, X Lin, J He, D Liu, L He… - Clinical and …, 2022 - Wiley Online Library
Background Rheumatoid arthritis (RA) is a chronic autoimmune disease. We previously
revealed that the natural compound artemisitene (ATT) exhibits excellent broad anticancer …

[HTML][HTML] NLRP12 attenuates ozone-induced pulmonary inflammation by regulating canonical NF-κB Pathway

M Li, Y Xue, X Miao, P Ma, X Kong, Y Jin, Y Li… - Ecotoxicology and …, 2023 - Elsevier
Ozone (O 3) is an important urban air pollutant having strong correlations with respiratory
diseases. Several lines of evidence suggest that O 3 exposure causes airway …

Novel isatin-based hybrids as potential anti-rheumatoid arthritis drug candidates: Synthesis and biological evaluation

J Chen, X Lin, J He, J Liu, J He, C Tao, Q Wang - Bioorganic chemistry, 2022 - Elsevier
Rheumatoid arthritis (RA) is an autoimmune disease accompanied with serious symptoms,
such as joint destruction and chronic synovitis. Though many anti-RA drugs could improve …

Galangin alleviates rheumatoid arthritis in rats by downregulating the phosphatidylinositol 3-kinase/protein kinase B signaling pathway

X Deng, H Le, T Wan, M Weng, Y Tan - Bioengineered, 2022 - Taylor & Francis
Rheumatoid arthritis (RA) is a chronic autoimmune disease that greatly affect patients'
quality of life. Galangin extract is renowned for its anti-proliferative and anti-oxidative …

CT2-3 induces cell cycle arrest and apoptosis in rheumatoid arthritis fibroblast-like synoviocytes through regulating PI3K/AKT pathway

J Chen, X Lin, K Liu, J He, X Li, C Zhang… - European Journal of …, 2023 - Elsevier
Rheumatoid arthritis (RA) is a kind of chronic autoimmune disease. The existing therapies
encountered several challenges. Therefore, continued novel anti-RA drug discovery …

[HTML][HTML] The role of NLRP12 in inflammatory diseases

L Huang, Y Tao, X Wu, J Wu, M Shen… - European Journal of …, 2023 - Elsevier
Nucleotide-binding leucine-rich repeat-containing receptor 12 (NLRP12), a highly
conserved protein containing an N-terminal pyrin domain (PYD), a nucleotide-binding …

Never-homozygous genetic variants in healthy populations are potential recessive disease candidates

T Schmenger, GD Diwan, G Singh, G Apic… - NPJ Genomic …, 2022 - nature.com
The rapid pace with which genetic variants are now being determined means there is a
pressing need to understand how they affect biological systems. Variants from healthy …

Inhibited Expression of NLRP12 Promotes the Development of Triple-Negative Breast Cancer by Activating the NF-κB Pathway

W Kuang, Q Gu, Y Zhou, X Xiao, D He… - Cell Biochemistry and …, 2023 - Springer
NLRP12 can affect the progression of different diseases, including hepatocellular
carcinoma. However, no report on triple-negative breast cancer (TNBC) has been found …