Glutamate is the most important excitatory neurotransmitter of the mammalian central
nervous system (CNS), playing an important role in memory, synaptic plasticity and neuronal …

It is estimated that the prevalence rate of Alzheimer's disease (AD) will double by the year
2040. Although currently available treatments help with symptom management, they do not …

Considerable evidence suggests that mitochondrial dysfunction and oxidative stress
contribute to the progression of Alzheimer's disease (AD). We examined the ability of the …

Alzheimer's disease (AD) is the most common form of dementia. It is characterized by
extracellular deposition of a specific protein, beta-amyloid peptide fibrils, and is …

Alzheimer's disease (AD) is associated with deficiencies in cerebrovascular functions, eg
reduced cerebral blood flow and capillary amyloid angiopathy, both of which are evident …

Brain inflammation, characterized by increased microglia and astrocyte activation, increases
during aging and is a key feature of neurodegenerative diseases, such as Alzheimer's …

Abstract Introduction The prevention of Alzheimer's disease (AD) has become a real
challenge due to its rising prevalence and the lack of an effective cure. Diet and nutrients …

Alzheimer's disease (AD) is the most common neurodegenerative disorder with
heterogeneous etiology. Intracellular neurofibrillary tangles caused by tau (τ) protein …

Alzheimer's disease (AD) is one of the most common forms of dementia among elder
people, which is a progressive neurodegenerative disease that results from a chronic loss of …

Found in all organisms, pyruvate dehydrogenase complexes (PDC) are the keystones of
prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi …