Highlights What are the main findings? Patients with the RSPH4A (c. 921+ 3_921+ 6del
(intronic)) founder mutation have low nNO levels. Adding new diagnostic tools such as nNO …

Introduction Primary ciliary dyskinesia is an autosomal recessive genetic disorder leading to
structural and/or functional abnormalities of motor cilia. Impaired mucociliary clearance is …

Background Primary ciliary dyskinesia (PCD) is an inherited disorder in which dyskinetic
cilia cause impaired mucociliary clearance of upper and lower airways. Airway ciliary …

Nitric oxide (NO) is both a gas and a ubiquitous inter-and intracellular messenger with
numerous physiological functions. As its synthesis is markedly increased during …

Nitric oxide (NO) is involved in a variety of biological functions including blood vessel
dilation and neurotransmitter release. In animals, NO has been demonstrated to affect …

Primary ciliary dyskinesia (PCD) is a rare genetic disorder affecting motile cilia in the
respiratory tract. 1 The estimated prevalence is 1: 7500 to 1: 15,000, although recent studies …

Primary ciliary dyskinesia (PCD) is a rare but underdiagnosed disorder that affects motile
cilia function throughout the body. With increasing prevalence through ongoing genetic …

Background A relationship between low levels of serum vitamin D and respiratory infections
has been established. No study has examined the frequency and clinical relevance of …

Primary ciliary dyskinesia (PCD) is a rare lung disease caused by mutations that impair the
function of motile cilia, resulting in chronic upper and lower respiratory disease, reduced …

Nitric oxide (NO), a small, gaseous signaling molecule, plays a vital role in numerous
processes such as hemodynamic maintenance, immune responses, and neurotransmission …