How the PhoP/PhoQ System Controls Virulence and Mg2+ Homeostasis: Lessons in Signal Transduction, Pathogenesis, Physiology, and Evolution
SUMMARY The PhoP/PhoQ two-component system governs virulence, Mg2+ homeostasis,
and resistance to a variety of antimicrobial agents, including acidic pH and cationic …
and resistance to a variety of antimicrobial agents, including acidic pH and cationic …
Feedback control of two-component regulatory systems
EA Groisman - Annual review of microbiology, 2016 - annualreviews.org
Two-component systems are a dominant form of bacterial signal transduction. The
prototypical two-component system consists of a sensor that responds to a specific input (s) …
prototypical two-component system consists of a sensor that responds to a specific input (s) …
[HTML][HTML] Evolution of Salmonella-Host Cell Interactions through a Dynamic Bacterial Genome
Salmonella Typhimurium has a broad arsenal of genes that are tightly regulated and
coordinated to facilitate adaptation to the various host environments it colonizes. The …
coordinated to facilitate adaptation to the various host environments it colonizes. The …
Bacterial battle against acidity
J Schwarz, K Schumacher, S Brameyer… - FEMS Microbiology …, 2022 - academic.oup.com
The Earth is home to environments characterized by low pH, including the gastrointestinal
tract of vertebrates and large areas of acidic soil. Most bacteria are neutralophiles, but can …
tract of vertebrates and large areas of acidic soil. Most bacteria are neutralophiles, but can …
Osmosensing by the bacterial PhoQ/PhoP two-component system
The PhoQ/PhoP two-component system plays an essential role in the response of
enterobacteria to the environment of their mammalian hosts. It is known to sense several …
enterobacteria to the environment of their mammalian hosts. It is known to sense several …
Salmonella promotes virulence by repressing cellulose production
Cellulose is the most abundant organic polymer on Earth. In bacteria, cellulose confers
protection against environmental insults and is a constituent of biofilms typically formed on …
protection against environmental insults and is a constituent of biofilms typically formed on …
[PDF][PDF] Reducing ribosome biosynthesis promotes translation during low Mg2+ stress
The synthesis of ribosomes is regulated by both amino acid abundance and the availability
of ATP, which regenerates guanosine triphosphate (GTP), powers ribosomes, and promotes …
of ATP, which regenerates guanosine triphosphate (GTP), powers ribosomes, and promotes …
Cellular Adaptations to Cytoplasmic Mg2+ Limitation
EA Groisman, C Chan - Annual review of microbiology, 2021 - annualreviews.org
Mg2+ is the most abundant divalent cation in living cells. It is essential for charge
neutralization, macromolecule stabilization, and the assembly and activity of ribosomes and …
neutralization, macromolecule stabilization, and the assembly and activity of ribosomes and …
Anti-infective activities of long-chain fatty acids against foodborne pathogens
C Borreby, EMS Lillebæk… - FEMS microbiology …, 2023 - academic.oup.com
Free fatty acids (FFAs) have long been acknowledged for their antimicrobial activity. More
recently, long-chain FFAs (> 12 carbon atoms) are receiving increased attention for their …
recently, long-chain FFAs (> 12 carbon atoms) are receiving increased attention for their …
Global RNA profiles show target selectivity and physiological effects of peptide-delivered antisense antibiotics
L Popella, J Jung, K Popova, S Ðurica-Mitić… - Nucleic acids …, 2021 - academic.oup.com
Antisense peptide nucleic acids (PNAs) inhibiting mRNAs of essential genes provide a
straight-forward way to repurpose our knowledge of bacterial regulatory RNAs for …
straight-forward way to repurpose our knowledge of bacterial regulatory RNAs for …