RNA splicing regulators play critical roles in neurogenesis
Alternative RNA splicing increases transcript diversity in different cell types and under
varying conditions. It is executed with the help of RNA splicing regulators (RSRs), which are …
varying conditions. It is executed with the help of RNA splicing regulators (RSRs), which are …
RNA modifications and RNA metabolism in neurological disease pathogenesis
B Chatterjee, CKJ Shen, P Majumder - International journal of molecular …, 2021 - mdpi.com
The intrinsic cellular heterogeneity and molecular complexity of the mammalian nervous
system relies substantially on the dynamic nature and spatiotemporal patterning of gene …
system relies substantially on the dynamic nature and spatiotemporal patterning of gene …
Diverse cell-specific patterns of alternative polyadenylation in Drosophila
Most genes in higher eukaryotes express isoforms with distinct 3'untranslated regions
(3'UTRs), generated by alternative polyadenylation (APA). Since 3'UTRs are predominant …
(3'UTRs), generated by alternative polyadenylation (APA). Since 3'UTRs are predominant …
Principles and correction of 5'-splice site selection
In Eukarya, immature mRNA transcripts (pre-mRNA) often contain coding sequences, or
exons, interleaved by non-coding sequences, or introns. Introns are removed upon splicing …
exons, interleaved by non-coding sequences, or introns. Introns are removed upon splicing …
Regulation of neuronal RNA signatures by ELAV/Hu proteins
V Hilgers - Wiley Interdisciplinary Reviews: RNA, 2023 - Wiley Online Library
The RNA‐binding proteins encoded by the highly conserved elav/Hu gene family, found in
all metazoans, regulate the expression of a wide range of genes, at both the co …
all metazoans, regulate the expression of a wide range of genes, at both the co …
Coordination of alternative splicing and alternative polyadenylation revealed by targeted long read sequencing
Nervous system development is associated with extensive regulation of alternative splicing
(AS) and alternative polyadenylation (APA). AS and APA have been extensively studied in …
(AS) and alternative polyadenylation (APA). AS and APA have been extensively studied in …
Investigating Cryptosporidium spp. Using Genomic, Proteomic and Transcriptomic Techniques: Current Progress and Future Directions
J Dąbrowska, J Sroka, T Cencek - International Journal of Molecular …, 2023 - mdpi.com
Cryptosporidiosis is a widespread disease caused by the parasitic protozoan
Cryptosporidium spp., which infects various vertebrate species, including humans. Once …
Cryptosporidium spp., which infects various vertebrate species, including humans. Once …
Bone morphogenetic protein signaling: the pathway and its regulation
T Akiyama, LA Raftery, KA Wharton - Genetics, 2024 - academic.oup.com
In the mid-1960s, bone morphogenetic proteins (BMPs) were first identified in the extracts of
bone to have the remarkable ability to induce heterotopic bone. When the Drosophila gene …
bone to have the remarkable ability to induce heterotopic bone. When the Drosophila gene …
RNAseq-based gene expression profiling of the Anopheles funestus pyrethroid-resistant strain FUMOZ highlights the predominant role of the duplicated CYP6P9a/b …
Insecticide-based interventions, notably long-lasting insecticidal nets, against mosquito
vectors of malaria are currently threatened by pyrethroid resistance. Here, we contrasted …
vectors of malaria are currently threatened by pyrethroid resistance. Here, we contrasted …
MAPP unravels frequent co-regulation of splicing and polyadenylation by RNA-binding proteins and their dysregulation in cancer
Maturation of eukaryotic pre-mRNAs via splicing and polyadenylation is modulated across
cell types and conditions by a variety of RNA-binding proteins (RBPs). Although there exist …
cell types and conditions by a variety of RNA-binding proteins (RBPs). Although there exist …