[HTML][HTML] Chlorogenic acid: Potential source of natural drugs for the therapeutics of fibrosis and cancer

EO Nwafor, P Lu, Y Zhang, R Liu, H Peng, B Xing… - Translational …, 2022 - Elsevier
Fibrosis and cancer is described by some epidemiological studies as chronic stages of
different disease conditions typically characterized by uncontrolled accumulation of extra …

A decade of research on coffee as an anticarcinogenic beverage

AD Nigra, AJ Teodoro, GA Gil - Oxidative Medicine and Cellular …, 2021 - Wiley Online Library
Coffee consumption has been investigated as a protective factor against cancer. Coffee is a
complex beverage that contains more than 1000 described phytochemicals, which are …

[HTML][HTML] The coffee diterpene, kahweol, ameliorates pancreatic β-cell function in streptozotocin (STZ)-treated rat INS-1 cells through NF-kB and p-AKT/Bcl-2 pathways

W El-Huneidi, S Anjum, K Bajbouj, E Abu-Gharbieh… - Molecules, 2021 - mdpi.com
Kahweol is a diterpene molecule found in coffee that exhibits a wide range of biological
activity, including anti-inflammatory and anticancer properties. However, the impact of …

Multispectroscopic and computational investigations on the binding mechanism of dicaffeoylquinic acids with ovalbumin

P Manivel, P Marimuthu, S Yu… - Journal of Chemical …, 2022 - ACS Publications
Recently, studies on the interactions between ovalbumin (OVA) and polyphenols have
received a great deal of interest. This study explored the conformational changes and the …

Current therapeutic targets and multifaceted physiological impacts of caffeine

X Song, N Kirtipal, S Lee, P Malý… - Phytotherapy …, 2023 - Wiley Online Library
Caffeine, which shares consubstantial structural similarity with purine adenosine, has been
demonstrated as a nonselective adenosine receptor antagonist for eliciting most of the …

[HTML][HTML] Colorectal Cancer Chemoprevention by S-Allyl Cysteine–Caffeic Acid Hybrids: In Vitro Biological Activity and In Silico Studies

A Herrera-Ramirez, AF Yepes-Pérez… - Scientia …, 2022 - mdpi.com
Conventional chemotherapy for colorectal cancer (CRC) gives only a small increase in
patient survival, since it is often diagnosed at late stages, when the tumor has disseminated …

[HTML][HTML] Inhibition of NLRP3 inflammasome activation by caffeine might be a potential mechanism to reduce the risk of squamous cell carcinoma of the oral cavity and …

FS Fan - Frontiers in Oral Health, 2022 - frontiersin.org
According to the GLOBOCAN 2020 assessment of cancer statistics generated by the
International Agency for Research on Cancer, cancer of the lip and oral cavity is the 18th …

Cafestol, Kahweol and Their Acylated Derivatives: Antitumor Potential, Pharmacokinetics, and Chemopreventive Profile

MAE Silva, ALM Brand, FJM Novaes… - Food Reviews …, 2023 - Taylor & Francis
Coffee is the food source of cafestol and kahweol (C&K), a pair of furanoditerpenoids that
have antitumor, anticarcinogenic and anti-inflammatory properties. These diterpenes act on …

New class of hybrids based on chalcone and melatonin: A promising therapeutic option for the treatment of colorectal cancer

AF Yepes, JD Arias, W Cardona-G, A Herrera-R… - Medicinal Chemistry …, 2021 - Springer
Considering that conventional chemotherapy provides only a limited increase of overall
survival for patients with colorectal cancer (CRC), and resistance is a major cause of …

[HTML][HTML] Evaluation of the Combined Effect of Caffeine and 5-Fluorouracil on Colorectal Cancer Cell Lines

F Khavari, M Taheri, H Manoochehri… - Asian Pacific Journal …, 2024 - ncbi.nlm.nih.gov
Background: Cancer is the second leading cause of death in the world. Colorectal cancer is
the third leading cause of cancer death. Today, there are several options for treating …