Flavonoids as potential therapeutic agents for the management of diabetic neuropathy

A Sood, B Kumar, SK Singh, P Prashar… - Current …, 2020 - ingentaconnect.com
Flavonoids are secondary metabolites that are widely distributed in plants. These phenolic
compounds are classified into various subgroups based on their structures: flavones …

Natural kinase inhibitors for the treatment and management of endometrial/uterine cancer: preclinical to clinical studies

RK Singla, S Behzad, J Khan, C Tsagkaris… - Frontiers in …, 2022 - frontiersin.org
Endometrial cancer (EC) is the sixth most prevalent type of cancer among women. Kinases,
enzymes mediating the transfer of adenosine triphosphate (ATP) in several signaling …

Alpha-Naphthoflavone as a Novel Scaffold for the Design of Potential Inhibitors of the APH(3')-IIIa Nucleotide-Binding Site of Enterococcus faecalis

JC Amorim, JM Carpio - Microorganisms, 2023 - mdpi.com
The spread of nosocomial infections caused by antibiotic-resistant Enterococcus faecalis is
one of the major threats to global health at present. While aminoglycosides are often used to …

Modulation of protein quality control systems by food phytochemicals

A Murakami - Journal of clinical biochemistry and nutrition, 2013 - jstage.jst.go.jp
There is compelling evidence showing that dietary phytochemicals have exhibited
pronounced bioactivities in a number of experimental models. In addition, a variety of …

Exploiting anti-inflammation effects of flavonoids in chronic inflammatory diseases

T Hussain, G Murtaza, H Yang… - Current …, 2020 - ingentaconnect.com
Background: Inflammation is a complex response of the host defense system to different
internal and external stimuli. It is believed that persistent inflammation may lead to chronic …

Anticancer potential of selected Fallopia Adans species

OT Olaru, L Venables, M Van De Venter… - Oncology …, 2015 - spandidos-publications.com
The aim of the present study was to determine the anticancer potential of three species
belonging to the Fallopia genus (Polygonaceae): Fallopia convolvulus (F. convolvulus …

Identification of histidine kinase inhibitors through screening of natural compounds to combat mastitis caused by Streptococcus agalactiae in dairy cattle

RK Pathak, JM Kim - Journal of Biological Engineering, 2023 - Springer
Background Mastitis poses a major threat to dairy farms globally; it results in reduced milk
production, increased treatment costs, untimely compromised genetic potential, animal …

Deciphering characteristics of Macaranga tanarius leaves extract with electron shuttle-associated anti-inflammatory activity via microbial fuel cells, molecular docking …

AGB Remorosa, PW Tsai, KA De Castro-Cruz… - Biochemical …, 2024 - Elsevier
Recent studies have shown that the potential disease-treating characteristics of traditional
Chinese medicine (TCM) were associated with electron-shuttling and bioenergy-stimulating …

Exploring the natural compounds in flavonoids for their potential inhibition of cancer therapeutic target MEK1 using computational methods

WM AlZahrani, SA AlGhamdi, TA Zughaibi, M Rehan - Pharmaceuticals, 2022 - mdpi.com
The Mitogen-Activated Protein Kinase (MAPK) signaling pathway plays an important role in
cancer cell proliferation and survival. MAPKs' protein kinases MEK1/2 serve as important …

The effects and mechanism of flavonoid–rePON1 interactions. Structure–activity relationship study

D Atrahimovich, J Vaya, S Khatib - Bioorganic & medicinal chemistry, 2013 - Elsevier
Flavonoids are plant phenolic secondary metabolites that are widely distributed in the
human diet. These antioxidants have received much attention because of their …