Succinate is an important metabolite at the cross-road of several metabolic pathways, also
involved in the formation and elimination of reactive oxygen species. However, it is …

Traditionally, the ketone body β-hydroxybutyrate (βOHB) has been looked upon as a carrier
of energy from liver to peripheral tissues during fasting or exercise. However, βOHB also …

Neurovascular integrity, including cerebral blood flow (CBF) and blood-brain barrier (BBB)
function, plays a major role in determining cognitive capability. Recent studies suggest that …

Cerebral ischemia/reperfusion injury activates microglia, resident immune cells in the brain,
and allows the infiltration of circulating immune cells into the ischemic lesions. Microglia play …

The ketone body β-hydroxybutyrate (BHB) is an endogenous factor protecting against stroke
and neurodegenerative diseases, but its mode of action is unclear. Here we show in a stroke …

Dietary and metabolic therapies have been attempted in a wide variety of neurological
diseases, including epilepsy, headache, neurotrauma, Alzheimer disease, Parkinson …

Abstract β-Hydroxybutyrate (βOHB), a ketone body, is oxidised as a brain fuel. Although its
contribution to energy metabolism in the healthy brain is minimal, it is an interesting …

An important concept in neurobiology is “neurons that fire together, wire together” which
means that the formation and maintenance of synapses is promoted by activation of those …

Previously, we proposed a new model for understanding the" Warburg effect" in tumor
metabolism. In this scheme, cancer-associated fibroblasts undergo aerobic glycolysis and …

The ketone body β-hydroxybutyrate (βOHB) is a convenient carrier of energy from
adipocytes to peripheral tissues during fasting or exercise. However, βOHB is more than just …