Amyotrophic lateral sclerosis (known in the UK as motor neuron disease) is a devastating
illness with uncertain pathogenesis. In this Seminar, we review its natural history, clinical …

Introduction Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder associated
with cognitive and behavioral impairments and motor symptoms. Magnetic resonance …

Target-based metabolomics, focused on a subset of metabolites representative of key
pathways, is a valuable tool for assessing metabolic changes resulting from genetic …

代谢组学是功能基因组学和系统生物学研究不可或缺的重要组成部分, 是通过考察生物体系受
刺激或扰动前后(如将某个特定的基因变异或环境变化后) 代谢产物的动态变化 …

Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disorder,
caused by the degeneration of upper and lower motor neurons for which there is no truly …

Levels of neurofilament subunits, potential biomarkers of motor axon breakdown, are
increased in amyotrophic lateral sclerosis (ALS) patient's CSF but data on blood are not …

Amyotrophic lateral sclerosis (ALS) is a fatal neurologic disease characterized by
progressive motor neuron degeneration. Clinical disease management is hindered by both …

The discovery of biomarkers for neurodegenerative diseases will have a major impact on the
efficiency of therapeutic clinical trials and may be important for understanding basic …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with
complicated pathogenesis with variable presentation and disease progression. There is a …

Magnetic resonance imaging measures have been proposed as objective markers to study
upper motor neuron loss in motor neuron disorders. Cross-sectional studies have identified …