The liver constitutes a key organ in systemic metabolism, contributing substantially to the
development of insulin resistance and type 2 diabetes mellitus (T2DM). The mechanisms …

Insulin signalling in the central nervous system regulates energy homeostasis by controlling
metabolism in several organs and by coordinating organ crosstalk. Studies performed in …

Hepatic steatosis is an underlying feature of nonalcoholic fatty liver disease (NAFLD), which
is the most common form of liver disease and is present in up to∼ 70% of individuals who …

Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to
the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular …

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
in Western countries that is predicted to become also the most frequent indication for liver …

Microplastics (MPs) are considered as a pollutant of marine environments and have become
a global environmental problem in recent years. A number of studies have demonstrated …

Inadequate or excessive nutrient consumption leads to oxidative stress, which may disrupt
oxidative homeostasis, activate a cascade of molecular pathways, and alter the metabolic …

Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease | New England
Journal of Medicine Skip to main content The New England Journal of Medicine homepage …

Nonalcoholic fatty liver disease (NAFLD) is a growing worldwide epidemic and an important
risk factor for the development of insulin resistance, type 2 diabetes, nonalcoholic …

Non-alcoholic fatty liver disease and its downstream sequelae, hepatic insulin resistance
and type 2 diabetes, are rapidly growing epidemics, which lead to increased morbidity and …