Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents
SC Benoit, CJ Kemp, CF Elias… - The Journal of …, 2009 - Am Soc Clin Investig
Insulin signaling can be modulated by several isoforms of PKC in peripheral tissues. Here,
we assessed whether one specific isoform, PKC-θ, was expressed in critical CNS regions …
we assessed whether one specific isoform, PKC-θ, was expressed in critical CNS regions …
Mechanisms of inflammatory responses in obese adipose tissue
The fields of immunology and metabolism are rapidly converging on adipose tissue. During
obesity, many immune cells infiltrate or populate in adipose tissue and promote a low-grade …
obesity, many immune cells infiltrate or populate in adipose tissue and promote a low-grade …
Human genetics uncovers MAP3K15 as an obesity-independent therapeutic target for diabetes
We performed collapsing analyses on 454,796 UK Biobank (UKB) exomes to detect gene-
level associations with diabetes. Recessive carriers of nonsynonymous variants in …
level associations with diabetes. Recessive carriers of nonsynonymous variants in …
The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways
D Gao, S Nong, X Huang, Y Lu, H Zhao, Y Lin… - Journal of Biological …, 2010 - ASBMB
Elevated plasma free fatty acid (FFA) levels in obesity may play a pathogenic role in the
development of insulin resistance. However, molecular mechanisms linking FFA to insulin …
development of insulin resistance. However, molecular mechanisms linking FFA to insulin …
Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler
Nonalcoholic fatty liver disease (NAFLD) affects one in three Americans and is a major
predisposing condition for the metabolic syndrome and type 2 diabetes (T2D). We examined …
predisposing condition for the metabolic syndrome and type 2 diabetes (T2D). We examined …
[PDF][PDF] Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects
S Haufe, S Engeli, P Kast, J Böhnke, W Utz… - …, 2011 - Wiley Online Library
Obesity‐related hepatic steatosis is a major risk factor for metabolic and cardiovascular
disease. Fat reduced hypocaloric diets are able to relieve the liver from ectopically stored …
disease. Fat reduced hypocaloric diets are able to relieve the liver from ectopically stored …
Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis
Non-alcoholic steatohepatitis (NASH), a cause of cirrhosis and hepatocellular carcinoma, is
characterized by fatty infiltration of the liver, inflammation, hepatocellular damage and …
characterized by fatty infiltration of the liver, inflammation, hepatocellular damage and …
Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease
JB Schwimmer, PE Pardee, JE Lavine, AK Blumkin… - Circulation, 2008 - Am Heart Assoc
Background—Nonalcoholic fatty liver disease (NAFLD), the most common cause of liver
disease in children, is associated with obesity and insulin resistance. However, the …
disease in children, is associated with obesity and insulin resistance. However, the …
Fatty liver and lipotoxicity
M Trauner, M Arrese, M Wagner - … et biophysica Acta (BBA)-Molecular and …, 2010 - Elsevier
Fatty liver disease comprises a spectrum ranging from simple steatosis to steatohepatitis
which can progress to liver cirrhosis and hepatocellular cancer. Hepatic lipotoxicity may …
which can progress to liver cirrhosis and hepatocellular cancer. Hepatic lipotoxicity may …
Consumption of red meat and whole-grain bread in relation to biomarkers of obesity, inflammation, glucose metabolism and oxidative stress
J Montonen, H Boeing, A Fritsche, E Schleicher… - European journal of …, 2013 - Springer
Purpose To examine the association of red meat and whole-grain bread consumption with
plasma levels of biomarkers related to glucose metabolism, oxidative stress, inflammation …
plasma levels of biomarkers related to glucose metabolism, oxidative stress, inflammation …