The epidemic of obesity has resulted in a parallel incremental burden of nonalcoholic fatty
liver disease (NAFLD) worldwide. Nonalcoholic fatty liver disease includes a spectrum of …

The term “fat” may refer to lipids as well as the cells and tissue that store lipid (ie, adipocytes
and adipose tissue).“Lipid” is derived from “lipos,” which refers to animal fat or vegetable oil …

Within the last twenty years the view on reactive oxygen species (ROS) has changed; they
are no longer only considered to be harmful but also necessary for cellular communication …

Obesity has been described as a global epidemic and is a low-grade chronic inflammatory
disease that arises as a consequence of energy imbalance. Obesity increases the risk of …

In obesity, macrophages and other immune cells accumulate in insulin target tissues,
promoting a chronic inflammatory state and insulin resistance. Galectin-3 (Gal3), a lectin …

Obesity is associated with an increased risk of nonalcoholic fatty liver disease (NAFLD).
Steatosis, the hallmark feature of NAFLD, occurs when the rate of hepatic fatty acid uptake …

Metabolic syndrome (MetS) is a disease composed of different risk factors such as obesity,
type 2 diabetes or dyslipidemia. The prevalence of this syndrome is increasing worldwide in …

Insulin resistance (IR) is fundamental to the development of type 2 diabetes (T2D) and is
present in most prediabetic (preDM) individuals. Insulin resistance has both heritable and …

Insulin resistance has long been associated with obesity. More than 40 years ago, Randle
and colleagues postulated that lipids impaired insulin-stimulated glucose use by muscles …

Acetylation is increasingly recognized as an important metabolic regulatory posttranslational
protein modification, yet the metabolic consequence of mitochondrial protein …