Excess caloric intake can lead to insulin resistance. The underlying reasons are complex but
likely related to ectopic lipid deposition in nonadipose tissue. We hypothesized that the …

The manner in which insulin resistance impinges on hepatic mitochondrial function is
complex. Although liver insulin resistance is associated with respiratory dysfunction, the …

Hepatic metabolic derangements are key components in the development of fatty liver,
insulin resistance, and atherosclerosis. SIRT1, a NAD+-dependent protein deacetylase, is …

Insulin resistance results from several pathophysiologic mechanisms, including chronic
tissue inflammation and defective insulin signaling. We found that liver, muscle and adipose …

Nonalcoholic fatty liver disease (NAFLD) is a major factor in the pathogenesis of type 2
diabetes (T2D) and nonalcoholic steatohepatitis (NASH). The mitochondrial protonophore 2 …

The prevalence of non-alcoholic fatty liver disease (NAFLD) is continually increasing due to
the global obesity epidemic. NAFLD comprises a systemic metabolic disease accompanied …

Although abnormal glucose metabolism defines type 2 diabetes mellitus (T2DM) and
accounts for many of its symptoms and complications, efforts to understand the …

Insulin resistance is a key feature of the metabolic syndrome and often progresses to type 2
diabetes. Both insulin resistance and type 2 diabetes are characterized by dyslipidemia …

Nonalcoholic fatty liver disease (NAFLD) is a global and growing health concern. Emerging
evidence points toward metabolic inflammation as a key process in the fatty liver that …

Abstract Background and Aim: Studies have shown monounsaturated oleic acid to be less
toxic than palmitic acid and to prevent/attenuate palmitic acid hepatocites toxicity in steatosis …