In this study, we investigated the effects of the major green tea polyphenol,(-)-
epigallocatechin-3-gallate (EGCG), on high-fat–induced obesity, symptoms of the metabolic …

As dietary exposure to fructose has increased over the past 40 years, there is growing
concern that high fructose consumption in humans may be in part responsible for the rising …

Calorie-enriched diet and lack of exercise are causing a worldwide surge of obesity, insulin
resistance and lipid accretion in liver (ie hepatic steatosis), which can lead to steatohepatitis …

We examined the hypothesis that insulin resistance in skeletal muscle promotes the
development of atherogenic dyslipidemia, associated with the metabolic syndrome, by …

Recent studies using magnetic resonance spectroscopy have shown that decreased insulin-
stimulated muscle glycogen synthesis due to a defect in insulin-stimulated glucose transport …

The esterification of a fatty acyl moiety to diacylglycerol to form triacylglycerol (TAG) is
catalysed by two diacylglycerol O-acyltransferases (DGATs) encoded by genes belonging to …

Type 2 diabetes mellitus is a major cause of morbidity and mortality worldwide, and the
prevalence is set to increase dramatically over the coming decades. Understanding the …

Adipose tissue (AT) secretes several adipokines that influence insulin sensitivity and
potentially link obesity to insulin resistance. Apelin, a peptide present in different tissues, is …

To further explore the nature of the mitochondrial dysfunction and insulin resistance that
occur in the muscle of young, lean, normoglycemic, insulin-resistant offspring of parents with …

Increased sugar consumption is increasingly considered to be a contributor to the worldwide
epidemics of obesity and diabetes and their associated cardiometabolic risks. As a result of …