The exercise IL-6 enigma in cancer
Abstract Interleukin (IL)-6 elicits both anticancer and procancer effects depending on the
context, which we have termed the 'exercise IL-6 enigma'. IL-6 is released from skeletal …
context, which we have termed the 'exercise IL-6 enigma'. IL-6 is released from skeletal …
[HTML][HTML] Upstream and downstream regulators of Klotho expression in chronic kidney disease
SS Li, M Sheng, ZY Sun, Y Liang, LX Yu, QF Liu - Metabolism, 2023 - Elsevier
Klotho is a critical protein that protects the kidney. Klotho is severely downregulated in
chronic kidney disease (CKD), and its deficiency is implicated in the pathogenesis and …
chronic kidney disease (CKD), and its deficiency is implicated in the pathogenesis and …
Immunomodulatory role of metalloproteinase ADAM17 in tumor development
K Wang, Z Xuan, X Liu, M Zheng, C Yang… - Frontiers in …, 2022 - frontiersin.org
ADAM17 is a member of the a disintegrin and metalloproteinase (ADAM) family of
transmembrane proteases involved in the shedding of some cell membrane proteins and …
transmembrane proteases involved in the shedding of some cell membrane proteins and …
Extracellular proteolysis in cancer: Proteases, substrates, and mechanisms in tumor progression and metastasis
ES Radisky - Journal of Biological Chemistry, 2024 - ASBMB
A vast ensemble of extracellular proteins influences the development and progression of
cancer, shaped and reshaped by a complex network of extracellular proteases. These …
cancer, shaped and reshaped by a complex network of extracellular proteases. These …
Oncogenic KRAS mutation confers chemoresistance by upregulating SIRT1 in non-small cell lung cancer
DH Shin, JY Jo, M Choi, KH Kim, YK Bae… - Experimental & Molecular …, 2023 - nature.com
Kirsten rat sarcoma viral oncogene homologue (KRAS) is a frequent oncogenic driver of
solid tumors, including non-small cell lung cancer (NSCLC). The treatment and outcomes of …
solid tumors, including non-small cell lung cancer (NSCLC). The treatment and outcomes of …
m6A-modified HOXC10 promotes HNSCC progression via co-activation of ADAM17/EGFR and Wnt/β-catenin signaling
Y Zhou, Q Huang, C Wu, Y Xu… - International …, 2023 - spandidos-publications.com
The homeobox (HOX) gene family plays a fundamental role in carcinogenesis. However, the
oncogenic mechanism of HOXC10 in head and neck squamous cell carcinoma (HNSCC) …
oncogenic mechanism of HOXC10 in head and neck squamous cell carcinoma (HNSCC) …
ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy
KB Piotrowski, LP Blasco, J Samsøe-Petersen… - Cancer Gene …, 2023 - nature.com
Radiotherapy is one of the most common cancer treatments, yet, some patients require high
doses to respond. Therefore, the development of new strategies leans toward personalizing …
doses to respond. Therefore, the development of new strategies leans toward personalizing …
Identification of molecular determinants in iRhoms1 and 2 that contribute to the substrate selectivity of stimulated ADAM17
Y Zhao, EM Dávila, X Li, B Tang… - International Journal of …, 2022 - mdpi.com
The metalloprotease ADAM17 is a key regulator of the TNFα, IL-6R and EGFR signaling
pathways. The maturation and function of ADAM17 is controlled by the seven-membrane …
pathways. The maturation and function of ADAM17 is controlled by the seven-membrane …
Loss of cancer cell‐derived ADAM15 alters the tumor microenvironment in colorectal tumors
L Puig‐Blasco, KB Piotrowski… - … Journal of Cancer, 2023 - Wiley Online Library
Tumor progression and response to treatment are highly affected by interactions between
cancer cells and the tumor microenvironment (TME). Many of the soluble factors and …
cancer cells and the tumor microenvironment (TME). Many of the soluble factors and …
Predictive Roles of ADAM17 in Patient Survival and Immune Cell Infiltration in Hepatocellular Carcinoma
T Ding, Y Yu, L Gao, L Xiang, B Xu, B Gu… - International Journal of …, 2023 - mdpi.com
Hepatocellular carcinoma (HCC) is the deadliest malignant tumour worldwide. The
metalloproteinase ADAM17 is associated with tumour formation and development; however …
metalloproteinase ADAM17 is associated with tumour formation and development; however …