Abstract Interleukin (IL)-6 elicits both anticancer and procancer effects depending on the
context, which we have termed the 'exercise IL-6 enigma'. IL-6 is released from skeletal …

Klotho is a critical protein that protects the kidney. Klotho is severely downregulated in
chronic kidney disease (CKD), and its deficiency is implicated in the pathogenesis and …

ADAM17 is a member of the a disintegrin and metalloproteinase (ADAM) family of
transmembrane proteases involved in the shedding of some cell membrane proteins and …

A vast ensemble of extracellular proteins influences the development and progression of
cancer, shaped and reshaped by a complex network of extracellular proteases. These …

Kirsten rat sarcoma viral oncogene homologue (KRAS) is a frequent oncogenic driver of
solid tumors, including non-small cell lung cancer (NSCLC). The treatment and outcomes of …

The homeobox (HOX) gene family plays a fundamental role in carcinogenesis. However, the
oncogenic mechanism of HOXC10 in head and neck squamous cell carcinoma (HNSCC) …

Radiotherapy is one of the most common cancer treatments, yet, some patients require high
doses to respond. Therefore, the development of new strategies leans toward personalizing …

The metalloprotease ADAM17 is a key regulator of the TNFα, IL-6R and EGFR signaling
pathways. The maturation and function of ADAM17 is controlled by the seven-membrane …

Tumor progression and response to treatment are highly affected by interactions between
cancer cells and the tumor microenvironment (TME). Many of the soluble factors and …

Hepatocellular carcinoma (HCC) is the deadliest malignant tumour worldwide. The
metalloproteinase ADAM17 is associated with tumour formation and development; however …