Artificial intelligence-enhanced drug design and development: Toward a computational precision medicine
Artificial Intelligence (AI) relies upon a convergence of technologies with further synergies
with life science technologies to capture the value of massive multi-modal data in the form of …
with life science technologies to capture the value of massive multi-modal data in the form of …
Next-generation genomics: an integrative approach
Integrating results from diverse experiments is an essential process in our effort to
understand the logic of complex systems, such as development, homeostasis and …
understand the logic of complex systems, such as development, homeostasis and …
Statistical strategies for avoiding false discoveries in metabolomics and related experiments
DI Broadhurst, DB Kell - Metabolomics, 2006 - Springer
Many metabolomics, and other high-content or high-throughput, experiments are set up
such that the primary aim is the discovery of biomarker metabolites that can discriminate …
such that the primary aim is the discovery of biomarker metabolites that can discriminate …
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases
DB Kell - BMC medical genomics, 2009 - Springer
Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …
The recurrent architecture of tumour initiation, progression and drug sensitivity
A Califano, MJ Alvarez - Nature Reviews Cancer, 2017 - nature.com
Recent studies across multiple tumour types are starting to reveal a recurrent regulatory
architecture in which genomic alterations cluster upstream of functional master regulator …
architecture in which genomic alterations cluster upstream of functional master regulator …
Inferring cellular networks–a review
F Markowetz, R Spang - BMC bioinformatics, 2007 - Springer
In this review we give an overview of computational and statistical methods to reconstruct
cellular networks. Although this area of research is vast and fast developing, we show that …
cellular networks. Although this area of research is vast and fast developing, we show that …
Statistical inference of the time-varying structure of gene-regulation networks
Background Biological networks are highly dynamic in response to environmental and
physiological cues. This variability is in contrast to conventional analyses of biological …
physiological cues. This variability is in contrast to conventional analyses of biological …
A single shot coherent Ising machine based on a network of injection-locked multicore fiber lasers
Combinatorial optimization problems over large and complex systems have many
applications in social networks, image processing, artificial intelligence, computational …
applications in social networks, image processing, artificial intelligence, computational …
Enhanced construction of gene regulatory networks using hub gene information
Background Gene regulatory networks reveal how genes work together to carry out their
biological functions. Reconstructions of gene networks from gene expression data greatly …
biological functions. Reconstructions of gene networks from gene expression data greatly …
Bayesian networks in renewable energy systems: A bibliographical survey
M Borunda, OA Jaramillo, A Reyes… - … and Sustainable Energy …, 2016 - Elsevier
For the last years, the research and development in the field of Renewable Energy has been
growing due to the need of Renewable Energy as an extended and reliable source of …
growing due to the need of Renewable Energy as an extended and reliable source of …