Artificial intelligence-enhanced drug design and development: Toward a computational precision medicine

P Moingeon, M Kuenemann, M Guedj - Drug discovery today, 2022 - Elsevier
Artificial Intelligence (AI) relies upon a convergence of technologies with further synergies
with life science technologies to capture the value of massive multi-modal data in the form of …

Next-generation genomics: an integrative approach

RD Hawkins, GC Hon, B Ren - Nature Reviews Genetics, 2010 - nature.com
Integrating results from diverse experiments is an essential process in our effort to
understand the logic of complex systems, such as development, homeostasis and …

Statistical strategies for avoiding false discoveries in metabolomics and related experiments

DI Broadhurst, DB Kell - Metabolomics, 2006 - Springer
Many metabolomics, and other high-content or high-throughput, experiments are set up
such that the primary aim is the discovery of biomarker metabolites that can discriminate …

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

DB Kell - BMC medical genomics, 2009 - Springer
Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

The recurrent architecture of tumour initiation, progression and drug sensitivity

A Califano, MJ Alvarez - Nature Reviews Cancer, 2017 - nature.com
Recent studies across multiple tumour types are starting to reveal a recurrent regulatory
architecture in which genomic alterations cluster upstream of functional master regulator …

Inferring cellular networks–a review

F Markowetz, R Spang - BMC bioinformatics, 2007 - Springer
In this review we give an overview of computational and statistical methods to reconstruct
cellular networks. Although this area of research is vast and fast developing, we show that …

Statistical inference of the time-varying structure of gene-regulation networks

S Lebre, J Becq, F Devaux, MPH Stumpf… - BMC systems …, 2010 - Springer
Background Biological networks are highly dynamic in response to environmental and
physiological cues. This variability is in contrast to conventional analyses of biological …

A single shot coherent Ising machine based on a network of injection-locked multicore fiber lasers

M Babaeian, DT Nguyen, V Demir, M Akbulut… - Nature …, 2019 - nature.com
Combinatorial optimization problems over large and complex systems have many
applications in social networks, image processing, artificial intelligence, computational …

Enhanced construction of gene regulatory networks using hub gene information

D Yu, J Lim, X Wang, F Liang, G Xiao - BMC bioinformatics, 2017 - Springer
Background Gene regulatory networks reveal how genes work together to carry out their
biological functions. Reconstructions of gene networks from gene expression data greatly …

Bayesian networks in renewable energy systems: A bibliographical survey

M Borunda, OA Jaramillo, A Reyes… - … and Sustainable Energy …, 2016 - Elsevier
For the last years, the research and development in the field of Renewable Energy has been
growing due to the need of Renewable Energy as an extended and reliable source of …