[HTML][HTML] Tocilizumab treatment in critically ill patients with COVID-19: A retrospective observational study
E Huang, S Isonaka, H Yang, E Salce… - International Journal of …, 2021 - Elsevier
Objective Elevated levels of pro-inflammatory cytokines are observed in severe COVID-19
infections, and cytokine storm is associated with disease severity. Tocilizumab, an …
infections, and cytokine storm is associated with disease severity. Tocilizumab, an …
Overview on the use of IL-6 agents in the treatment of patients with cytokine release syndrome (CRS) and pneumonitis related to COVID-19 disease
Z Zhou, CC Price - Expert opinion on investigational drugs, 2020 - Taylor & Francis
Introduction A novel coronavirus pneumonia (COVID-19) has caused significant life loss and
healthcare burden globally. COVID-19 is known to cause a cytokine release syndrome …
healthcare burden globally. COVID-19 is known to cause a cytokine release syndrome …
[HTML][HTML] A propensity-matched cohort study of tocilizumab in patients with coronavirus disease 2019
TC Lewis, S Adhikari, V Tatapudi, M Holub… - Critical care …, 2020 - journals.lww.com
Objectives: To determine the impact of tocilizumab, a monoclonal antibody against the
interleukin 6 receptor, on survival in patients with coronavirus disease 2019. Design …
interleukin 6 receptor, on survival in patients with coronavirus disease 2019. Design …
[HTML][HTML] Surviving the storm: cytokine biosignature in SARS-CoV-2 severity prediction
R Ahmad, M Haque - Vaccines, 2022 - mdpi.com
Simple Summary The world has been stricken mentally, physically, and economically by the
COVID-19 virus. However, while SARS-CoV-2 viral infection results in mild flu-like symptoms …
COVID-19 virus. However, while SARS-CoV-2 viral infection results in mild flu-like symptoms …
Identification and development of therapeutics for COVID-19
After emerging in China in late 2019, the novel coronavirus severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) spread worldwide, and as of mid-2021, it remains a …
syndrome coronavirus 2 (SARS-CoV-2) spread worldwide, and as of mid-2021, it remains a …
[HTML][HTML] Dynamic of serum TWEAK levels in critically ill COVID-19 male patients
M Mikacic, M Kumric, M Baricevic, D Tokic… - Journal of clinical …, 2022 - mdpi.com
Although the number of cases and mortality of COVID-19 are seemingly declining, clinicians
endeavor to establish indicators and predictors of such responses in order to optimize …
endeavor to establish indicators and predictors of such responses in order to optimize …
[HTML][HTML] Treating COVID-19: Evolving approaches to evidence in a pandemic
CK Lee, LT Merriam, JC Pearson, MS Lipnick… - Cell Reports …, 2022 - cell.com
The rapid pace of the COVID-19 pandemic precluded traditional approaches to evaluating
clinical research and guidelines. We highlight notable successes and pitfalls of clinicians' …
clinical research and guidelines. We highlight notable successes and pitfalls of clinicians' …
Prevalence of symptoms in patients discharged from COVID care facility of NIMS hospital: Is RT PCR negativity truly reflecting recovery? A single-centre observational …
Purpose To assess the prevalence of post-COVID symptoms in patients with recovered
COVID-19 (nasopharyngeal RT PCR negative) who were discharged from an acute COVID …
COVID-19 (nasopharyngeal RT PCR negative) who were discharged from an acute COVID …
A randomized placebo-controlled trial of sarilumab in hospitalized patients with Covid-19
S Sivapalasingam, DJ Lederer, R Bhore, N Hajizadeh… - MedRxiv, 2021 - medrxiv.org
ABSTRACT BACKGROUND Sarilumab (anti-interleukin-6 receptor-α monoclonal antibody)
may attenuate the inflammatory response in Covid-19. METHODS We performed an …
may attenuate the inflammatory response in Covid-19. METHODS We performed an …
[HTML][HTML] Thrombotic events following tocilizumab therapy in critically ill COVID-19 patients: a Façade for prognostic markers
Abstract Background Hospitals in the Middle East Gulf region have experienced an influx of
COVID-19 patients to their medical wards and intensive care units. The hypercoagulability of …
COVID-19 patients to their medical wards and intensive care units. The hypercoagulability of …