To immunosuppress: whom, when and how? That is the question with COVID-19

KL Winthrop, X Mariette - Annals of the rheumatic diseases, 2020 - ard.bmj.com
In ARD, Ramiro et al report a number of sophisticated primary and sensitivity analyses from
an observational cohort study conducted in the Netherlands during the height of the COVID …

Tocilizumab in coronavirus disease 2019-related critical illness: a propensity matched analysis

P Rajendram, GL Sacha, O Mehkri, X Wang… - Critical care …, 2021 - journals.lww.com
Objectives: The primary objective was to evaluate ICU mortality at 28 days in patients with
severe hypoxemic respiratory failure due to coronavirus disease 2019 infection who …

Angiotensin enzyme inhibitors and angiotensin receptor blockers as protective factors in COVID-19 mortality: a retrospective cohort study

A Yahyavi, N Hemmati, P Derakhshan… - Internal and emergency …, 2021 - Springer
Targeting the renin-angiotensin system is proposed to affect mortality due to coronavirus
disease 2019 (COVID-19). We aimed to compare the mortality rates in COVID-19 patients …

[HTML][HTML] Treatment with Tocilizumab in Adult Patients with Moderate to Critical COVID‐19 Pneumonia: A Single‐Center Retrospective Study

A Radulescu, A Istrate, M Muntean - International Journal of Infectious …, 2022 - Elsevier
Objectives This study aimed to assess if tocilizumab (TCZ) timing is associated with
improved survival. Material and methods Data obtained from adult patients with …

Mortality and pulmonary embolism in acute respiratory distress syndrome from COVID-19 vs. non-COVID-19

DJ Kutsogiannis, A Alharthy, A Balhamar… - Frontiers in …, 2022 - frontiersin.org
Purpose There may be a difference in respiratory mechanics, inflammatory markers, and
pulmonary emboli in COVID-19 associated ARDS vs. ARDS from other etiologies. Our …

Interleukin‐6 inhibitory effect of natural product naringenin compared to a synthesised monoclonal antibody against life‐threatening COVID‐19

M AmeliMojarad… - Reviews in Medical …, 2023 - Wiley Online Library
Abstract Coronavirus Disease 2019 (COVID‐19) has become a global pandemic in 2020
with high patient mortality due to acute respiratory distress syndrome which is possibly …

Anti-inflammatory properties of drugs used to control COVID-19 and their effects on the renin-angiotensin system and angiotensin-converting enzyme-2

H Gilzad-Kohan, F Jamali - Journal of Pharmacy & …, 2020 - journals.library.ualberta.ca
COVID-19 infection is associated with systemic inflammation, and sometimes
hyperinflammatory responses with cytokine storm. This plays a major role in COVID-19 …

Administration timing and efficacy of tocilizumab in patients with COVID-19 and elevated IL-6

P Li, Z Lu, Q Li, Z Wang, Y Guo, C Cai… - Frontiers in molecular …, 2021 - frontiersin.org
Background Tocilizumab (TCZ), an interleukin-6 receptor antibody, has previously been
used for treating patients with the coronavirus disease 2019 (COVID-19), but there is a lack …

A randomized double-blinded placebo controlled trial of clazakizumab for the treatment of COVID-19 pneumonia with hyperinflammation

BE Lonze, P Spiegler, RN Wesson… - Critical care …, 2022 - journals.lww.com
OBJECTIVES: We designed this study to test whether clazakizumab, a direct interleukin-6
inhibitor, benefits patients hospitalized with severe or critical COVID-19 disease …

Serotype and clonal distribution dynamics of invasive pneumococcal strains after PCV13 introduction (2011-2016): Surveillance data from 23 sites in Catalonia, Spain

G Ludwig, S Garcia-Garcia, M Lanaspa, P Ciruela… - PLoS …, 2020 - journals.plos.org
Background The objective of this study is to describe incidence and shifts of serotype and
clonal distribution of invasive Streptococcus pneumoniae strains in four different age groups …