The liver cancer immune microenvironment: Therapeutic implications for hepatocellular carcinoma
R Donne, A Lujambio - Hepatology, 2023 - journals.lww.com
The liver is the sixth most common site of primary cancer in humans and the fourth leading
cause of cancer‐related death in the world. Hepatocellular carcinoma (HCC) accounts for …
cause of cancer‐related death in the world. Hepatocellular carcinoma (HCC) accounts for …
Overcoming TGFβ-mediated immune evasion in cancer
Transforming growth factor-β (TGFβ) signalling controls multiple cell fate decisions during
development and tissue homeostasis; hence, dysregulation of this pathway can drive …
development and tissue homeostasis; hence, dysregulation of this pathway can drive …
Exploring the NK cell platform for cancer immunotherapy
JA Myers, JS Miller - Nature reviews Clinical oncology, 2021 - nature.com
Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system that are
capable of killing virally infected and/or cancerous cells. Nearly 20 years ago, NK cell …
capable of killing virally infected and/or cancerous cells. Nearly 20 years ago, NK cell …
The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy
D Bruni, HK Angell, J Galon - Nature Reviews Cancer, 2020 - nature.com
Abstract The international American Joint Committee on Cancer/Union for International
Cancer Control (AJCC/UICC) tumour-node-metastasis (TNM) staging system provides the …
Cancer Control (AJCC/UICC) tumour-node-metastasis (TNM) staging system provides the …
Natural killer cells in cancer biology and therapy
SY Wu, T Fu, YZ Jiang, ZM Shao - Molecular cancer, 2020 - Springer
The tumor microenvironment is highly complex, and immune escape is currently considered
an important hallmark of cancer, largely contributing to tumor progression and metastasis …
an important hallmark of cancer, largely contributing to tumor progression and metastasis …
Natural killer cell homing and trafficking in tissues and tumors: from biology to application
GH Ran, YQ Lin, L Tian, T Zhang, DM Yan… - Signal transduction and …, 2022 - nature.com
Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense
against cancer. Although some evidence shows that NK cells can develop in secondary …
against cancer. Although some evidence shows that NK cells can develop in secondary …
TIGIT, the next step towards successful combination immune checkpoint therapy in cancer
Z Ge, MP Peppelenbosch, D Sprengers… - Frontiers in …, 2021 - frontiersin.org
T cell immunoreceptor with Ig and ITIM domains (TIGIT) is an inhibitory receptor expressed
on several types of lymphocytes. Efficacy of antibody blockade of TIGIT in cancer …
on several types of lymphocytes. Efficacy of antibody blockade of TIGIT in cancer …
Hepatocellular carcinoma immune landscape and the potential of immunotherapies
Hepatocellular carcinoma (HCC) is the most common liver tumor and among the deadliest
cancers worldwide. Advanced HCC overall survival is meager and has not improved over …
cancers worldwide. Advanced HCC overall survival is meager and has not improved over …
NK cell-based immune checkpoint inhibition
Immunotherapy, with an increasing number of therapeutic dimensions, is becoming an
important mode of treatment for cancer patients. The inhibition of immune checkpoints …
important mode of treatment for cancer patients. The inhibition of immune checkpoints …
Tumor immunology and tumor evolution: intertwined histories
J Galon, D Bruni - Immunity, 2020 - cell.com
Cancer is a complex disease whose outcome depends largely on the cross-talk between the
tumor and its microenvironment. Here, we review the evolution of the field of tumor …
tumor and its microenvironment. Here, we review the evolution of the field of tumor …