Mammalian fertilization initiates the reprogramming of oocytes and sperm, forming a
totipotent zygote. During this intricate process, the zygotic genome undergoes a maternal-to …

Alzheimer's disease (AD) is a devastating neurodegenerative disease with limited
therapeutic options. Cellular transplantation of healthy exogenic neurons to replace and …

Thus far, the potential short-and long-term detrimental effects of a variety of environmental
chemicals designated as endocrine-active compounds (EACs) have been found to interfere …

Background The transcriptional changes around zygotic genome activation (ZGA) in
preimplantation embryos are critical for studying mechanisms of embryonic developmental …

The present study sought to establish the mitotically stable adult cutaneous fibroblast cell
(ACFC) lines stemming from h FUT2× h GLA× HLA-E triple-transgenic pigs followed by …

Thus far, nearly 25 mammalian species have been cloned by intra-or interspecies somatic
cell nuclear transfer (SCNT). Among them, non-transgenic and transgenic representatives of …

The nucleolus is the most prominent liquid droplet-like membrane-less organelle in
mammalian cells. Unlike the nucleolus in terminally differentiated somatic cells, those in …

The technique of pig cloning holds great promise for the livestock industry, life science, and
biomedicine. However, the prenatal death rate of cloned pig embryos is extremely high …

Sika deer inhabiting South Korea became extinct when the last individual was captured on
Jeju Island in Korea in 1920 owing to the Japanese seawater relief business, but it is …

The epigenetic modification levels of donor cells directly affect the developmental potential
of somatic cell nuclear transfer (SCNT) embryos. BRG1, as an epigenetic modifying enzyme …