Although it was thought that apoptotic cells, when rapidly phagocytosed, underwent a silent
death that did not trigger an immune response, in recent years a new concept of …

Macrophages are a specialized class of innate immune cells with multifaceted roles in
modulation of the inflammatory response, homeostasis, and wound healing. While …

The observation that a subset of cancer patients show evidence for spontaneous CD8+ T
cell priming against tumor-associated antigens has generated renewed interest in the innate …

Established tumors are typified by an immunosuppresive microenvironment. Countering this
naturally occurring phenomenon, emerging evidence suggests that radiation promotes a …

The therapeutic efficacy of anthracyclines relies on antitumor immune responses elicited by
dying cancer cells. How chemotherapy-induced cell death leads to efficient antigen …

Sepsis is characterized by a systemic inflammatory response followed by
immunosuppression of the host. Metabolic defects and mitochondrial failure are common in …

Surface‐exposed calreticulin (ecto‐CRT) and secreted ATP are crucial damage‐associated
molecular patterns (DAMPs) for immunogenic apoptosis. Inducers of immunogenic …

The immunogenic demise of cancer cells can be induced by various chemotherapeutics,
such as anthracyclines and oxaliplatin, and provokes an immune response against tumor …

The traditional view holds that apoptosis is non-immunogenic and does not induce an
inflammatory response. However, recent studies have suggested that certain …

It has recently become clear that the tumour microenvironment, and in particular the immune
system, has a crucial role in modulating tumour progression and response to therapy …